Evidence map›Paper›PMID 37503115›Full record

ArticlebioRxiv : the preprint server for biology2023

Cdc42 mobility and membrane flows regulate fission yeast cell shape and survival.

David M Rutkowski, Vincent Vincenzetti, Dimitrios Vavylonis, Sophie G Martin

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 7 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

David M RutkowskiDepartment of Physics, Lehigh University, Bethlehem PA, USA.
Vincent VincenzettiDepartment of Fundamental Microbiology, University of Lausanne, Switzerland.
Dimitrios VavylonisDepartment of Physics, Lehigh University, Bethlehem PA, USA.
Sophie G MartinDepartment of Fundamental Microbiology, University of Lausanne, Switzerland.
Lehigh University · USUniversity of Geneva · CHUniversity of Lausanne · CH

Funding

Modeling mechanisms in cytokinesis, cell polarization and motilityR35GM136372 · NIGMS · LEHIGH UNIVERSITY · PI Dimitrios Vavylonis · 2020 to 2026
$3.2M
NIGMS NIH HHS R35 GM136372
6 · The paper itself

Abstract

Local Cdc42 GTPase activation promotes polarized exocytosis, resulting in membrane flows that deplete low-mobility membrane-associated proteins from the growth region. To investigate the self-organizing properties of the Cdc42 secretion-polarization system under membrane flow, we developed a reaction-diffusion particle model. The model includes positive feedback activation of Cdc42, hydrolysis by GTPase-activating proteins (GAPs), and flow-induced displacement by exo/endocytosis. Simulations show how polarization relies on flow-induced depletion of low mobility GAPs. To probe the role of Cdc42 mobility in the fission yeast

Indexed as

Cdc42 GTPaseCell polarizationmembrane flowsreaction-diffusion systemssymmetry breaking

Identifiers

PMID37503115
PMCPMC10370159
OpenAlexW4385074115

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.