Evidence map›Paper›PMID 37503105›Full record

ArticlebioRxiv : the preprint server for biology2023

Membrane mechanics dictate axonal morphology and function.

Jacqueline M Griswold, Mayte Bonilla-Quintana, Renee Pepper, Christopher T Lee, Sumana Raychaudhuri, Siyi Ma, Quan Gan, Sarah Syed, Cuncheng Zhu, Miriam Bell and 7 more

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 7 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 6 institutions in 5 countries.

Jacqueline M Griswold
Mayte Bonilla-Quintana
Renee Pepper
Christopher T LeeORCID 0000-0002-0670-2308
Sumana Raychaudhuri
Siyi Ma
Quan Gan
Sarah Syed
Miriam Bell
Mitsuo Suga
Yuuki Yamaguchi
Ronan Chéreau
U Valentin NägerlORCID 0000-0001-6831-9008
Graham Knott
Padmini RangamaniORCID 0000-0001-5953-4347
Shigeki Watanabe
Johns Hopkins University · USUniversity of California San Diego · USJEOL (Japan) · JPUniversité de Bordeaux · FRÉcole Polytechnique Fédérale de Lausanne · CHMarine Biological Laboratory · US

Funding

Ultrafast membrane trafficking at synapsesR35NS132153 · NINDS · JOHNS HOPKINS UNIVERSITY · PI Shigeki Watanabe · 2023 to 2026
$4.1M
Reviving electron microscopy for synaptic cell biologyDP2NS111133 · NINDS · JOHNS HOPKINS UNIVERSITY · PI WATANABE, SHIGEKI · 2018 to 2018
$2.5M
Spatial and molecular determinants of fusion probability and timingR01NS105810 · NINDS · JOHNS HOPKINS UNIVERSITY · PI WATANABE, SHIGEKI · 2018 to 2022
$1.8M
NINDS NIH HHS DP2 NS111133NINDS NIH HHS R01 NS105810NINDS NIH HHS R35 NS132153
6 · The paper itself

Abstract

Axons are thought to be ultrathin membrane cables of a relatively uniform diameter, designed to conduct electrical signals, or action potentials. Here, we demonstrate that unmyelinated axons are not simple cylindrical tubes. Rather, axons have nanoscopic boutons repeatedly along their length interspersed with a thin cable with a diameter of ∼60 nm like pearls-on-a-string. These boutons are only ∼200 nm in diameter and do not have synaptic contacts or a cluster of synaptic vesicles, hence non-synaptic. Our

Identifiers

PMID37503105
PMCPMC10370128
OpenAlexW4385144472

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.