Evidence map›Paper›PMID 37503102›Full record

ArticleResearch square2023

A parainfluenza virus 5 (PIV5)-vectored intranasal vaccine for Lyme disease provides long-lasting protection against tick transmitted

Maria Cristina Gingerich, Nisha Nair, J Filipe Azevedo, Kamalika Samanta, Suman Kundu, Biao He, Maria Gomes-Solecki

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Maria Cristina GingerichDepartment of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA, USA.
Nisha NairDepartment of Microbiology, Immunology, and Biochemistry, University of Tennessee Health Science Center, Tennessee, USA.
J Filipe AzevedoDepartment of Microbiology, Immunology, and Biochemistry, University of Tennessee Health Science Center, Tennessee, USA.
Kamalika SamantaDepartment of Microbiology, Immunology, and Biochemistry, University of Tennessee Health Science Center, Tennessee, USA.ORCID 0000-0001-6456-601X
Suman KunduDepartment of Microbiology, Immunology, and Biochemistry, University of Tennessee Health Science Center, Tennessee, USA.
Biao HeDepartment of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA, USA.
Maria Gomes-SoleckiDepartment of Microbiology, Immunology, and Biochemistry, University of Tennessee Health Science Center, Tennessee, USA.ORCID 0000-0002-3715-4543
University of Tennessee Health Science Center · USGeorgia College & State University · US

Funding

Field trial and modeling of transmission blocking vaccine to prevent Lyme diseaseR01AI139267 · NIAID · UNIVERSITY OF IOWA · PI BROWN, GRANT D, GOMES-SOLECKI, MARIA · 2019 to 2023
$3.6M
Intranasal Vaccine Against Lyme DiseaseR44AI167605 · NIAID · IMMUNO TECHNOLOGIES, INC. · PI GOMES-SOLECKI, MARIA · 2022 to 2024
$3.0M
Antibody isotyping for discrimination of disease stage and diagnosis of early Lyme disease.R43AI155211 · NIAID · IMMUNO TECHNOLOGIES, INC. · PI GOMES-SOLECKI, MARIA · 2020 to 2021
$594k
NIAID NIH HHS R01 AI139267NIAID NIH HHS R43 AI155211NIAID NIH HHS R44 AI167605
6 · The paper itself

Abstract

Lyme disease (LD) is the most prevalent vector borne disease in North America and Europe and its geographic range continues to expand. Strategies for disease control are necessary to effectively reduce incidence of LD including development of safe vaccines for human use. Parainfluenza virus 5 (PIV5) vector has an excellent safety record in animals and PIV5-vectored COVID-19 and RSV vaccines are currently under clinical development. We constructed PIV5-vectored LD vaccine candidates expressing OspA from

Identifiers

PMID37503102
PMCPMC10371166
OpenAlexW4384698033

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.