ArticleResearch square2023
Metabolomic Profiles of Sleep-Disordered Breathing are Associated with Hypertension and Diabetes Mellitus Development: the HCHS/SOL.
Tamar Sofer, Ying Zhang, Bing Yu, Qibin Qi, Ali Azarbarzin, Han Chen, Neomi Shah, Alberto Ramos, Phyllis Zee, Jianwen Cai and 5 more
Open access · greenAbstract readPreprint
In one paragraphArticle in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
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0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 0 citations in OpenAlex.
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
15 authors at 8 institutions in 1 country.
Qibin QiAlbert Einstein College of Medicine.
Ali AzarbarzinBrigham and Women's Hospital.
Han ChenThe University of Texas Health Science Center at Houston.
Neomi ShahIcahn School of Medicine at Mount Sinai.
Alberto RamosUniversity of Miami Miller School of Medicine.
Phyllis ZeeNorthwestern University Feinberg School of Medicine.
Jianwen CaiUniversity of North Carolina.
Martha DaviglusUniversity of Illinois at Chicago.
Eric BoerwinkleUniversity of Texas Health Science Center at Houston.
Robert KaplanAlbert Einstein College of Medicine.
Peter LiuLundquist Institute at Harbor-UCLA Medical Center.
Brigham and Women's Hospital · USAlbert Einstein College of Medicine · USThe University of Texas Health Science Center at Houston · USHarbor–UCLA Medical Center · USHarvard University Press · USIcahn School of Medicine at Mount Sinai · USUniversity of Illinois Chicago · USUniversity of Miami · US
Funding
Pilot Program CoreP30ES027792 · NIEHS · UNIVERSITY OF CHICAGO · PI Gokhan M. Mutlu, Gail S Prins · 2017 to 2026
$13.6MNew York Regional Center for Diabetes Translation Research - Translational Intervention Methodology CoreP30DK111022 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI JEFFREY GONZALEZ · 2016 to 2026
$7.8MPhenotypic and Molecular Signatures for Sleep Apnea and Related MorbiditiesR35HL135818 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI REDLINE, SUSAN S. · 2017 to 2023
$7.2MImaging the Atherosclerosis Cascade in Sleep ApneaR01HL143221 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI SHAH, NEOMI A · 2018 to 2022
$4.2MLeveraging omics data to understand sleep health and its consequences among diverse Hispanics/LatinosR01HL161012 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI Tamar Sofer · 2022 to 2026
$3.2MThalassemia Clinical Research Network, CanadaU01HL065233 · NHLBI · UNIVERSITY HEALTH NETWORK · PI OLIVIERI, NANCY F · 2000 to 2009
$2.6MApplication of Machine Learning to Identify Obstructive Sleep Apnea Subgroups at Risk for Atherosclerosis Progression and Cardiovascular Disease Events (OSA-GRANDE)R01HL168897 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Girish Nitin Nadkarni, Mayte Suarez-Farinas · 2024 to 2026
$2.3MGENETIC ARCHITECTURE OF PLASMA T-PA AND PAI-1R01HL065234 · NHLBI · VANDERBILT UNIVERSITY · PI MOORE, JASON H. · 2000 to 2004
$1.7MHISPANIC COMMUNITY HEALTH STUDY-268065233N01HC065233 · HC · COORDINATING CENTER · PI CHAMBLESS, LLOYD E · 2006 to 2006
–NHGRI NIH HHS HHSN268201300003CNHLBI NIH HHS HHSN268201300001CNHLBI NIH HHS HHSN268201300004CNHLBI NIH HHS HHSN268201300005CNHLBI NIH HHS N01 HC065233NHLBI NIH HHS N01 HC065234NHLBI NIH HHS N01 HC065235NHLBI NIH HHS N01 HC065236NHLBI NIH HHS N01 HC065237NHLBI NIH HHS R01 HL143221NHLBI NIH HHS R01 HL161012NHLBI NIH HHS R01 HL168897NHLBI NIH HHS R35 HL135818NIDDK NIH HHS P30 DK111022NIEHS NIH HHS P30 ES027792
6 · The paper itselfAbstract
Sleep-disordered breathing (SDB) is a prevalent disorder characterized by recurrent episodic upper airway obstruction. In a dataset from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL), we applied principal component analysis (PCA) on seven measures characterizing SDB-associated respiratory events. We estimated the association of the top two SDB PCs with serum levels of 617 metabolites, in both single-metabolite analysis, and a joint, penalized regression analysis using the least absolute shrinkage and selection operator (LASSO). Discovery analysis included n = 3,299 HCHS/SOL individuals; associations were validated in a separate dataset of n = 1,522 HCHS/SOL individuals. Seven metabolite associations with SDB PCs were discovered and replicated. Metabolite risk scores (MRSs) developed based on LASSO association results and representing metabolite signatures associated with the two SDB PCs were associated with 6-year incident hypertension and incident diabetes. MRSs have the potential to serve as biomarkers for SDB, guiding risk stratification and treatment decisions.
Identifiers
PMID37503089
PMCPMC10371150
OpenAlexW4384944236
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