Evidence map›Paper›PMID 37503077›Full record

ArticleResearch square2023

Cooperative Genomic Lesions in HRAS-Mutant Cancers Predict Resistance to Farnesyltransferase Inhibitors.

Aradhya Nigam, Gnana Krishnamoorthy, Walid Chatila, Katherine Berman, Mahesh Saqcena, Henry Walch, Alan Ho, Nikolaus Schultz, James Fagin, Brian Untch

Open access · greenAbstract readPreprint
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Aradhya NigamMemorial Sloan Kettering Cancer Center.ORCID 0000-0002-1174-3307
Gnana KrishnamoorthyMemorial Sloan Kettering Cancer Center.ORCID 0000-0002-6139-5435
Walid ChatilaMemorial Sloan-Kettering Cancer Center.
Katherine BermanMemorial Sloan-Kettering Cancer Center.
Mahesh SaqcenaMemorial Sloan-Kettering Cancer Center.
Henry WalchMemorial Sloan-Kettering Cancer Center.
Alan HoMemorial Sloan-Kettering Cancer Center.
Nikolaus SchultzCenter for Molecular Oncology, Memorial Sloan Kettering Cancer Center.ORCID 0000-0002-0131-4904
James FaginMemorial Sloan Kettering Cancer Center.ORCID 0000-0002-2365-2517
Brian UntchMemorial Sloan Kettering Cancer Center.
Memorial Sloan Kettering Cancer Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
HEAD AND NECK TRAINING PROGRAM SURGICAL ONCOLOGYT32CA009685 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI FAGIN, JAMES A, WONG, RICHARD J · 1992 to 2022
$3.6M
Improving efficacy of radioiodine treatment of thyroid cancerR01CA249663 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI FAGIN, JAMES A, HO, ALAN L. · 2021 to 2025
$2.3M
NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA249663NCI NIH HHS T32 CA009685
6 · The paper itself

Abstract

The clinical development of farnesyltransferase inhibitors (FTI) for

Identifiers

PMID37503077
PMCPMC10371077
OpenAlexW4384282730

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.