Evidence map›Paper›PMID 37503068›Full record

ArticleResearch square2023

ARG1 is a potential prognostic marker in metastatic and recurrent endometrial cancer.

Dinh Nam Tran, Valery Rozen, Mark I Hunter, Tae Hoon Kim, Jae-Wook Jeong

Open access · greenAbstract readPreprint
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Dinh Nam TranUniversity of Missouri School of Medicine.
Valery RozenMichigan State University College of Human Medicine.
Mark I HunterUniversity of Missouri School of Medicine.
Tae Hoon KimUniversity of Missouri School of Medicine.
Jae-Wook JeongUniversity of Missouri School of Medicine.ORCID 0000-0002-5368-6478
University of Missouri · USMichigan State University · US

Funding

The role of cholesterol biosynthesis in metastatic and recurrent endometrialcancerR01CA264944 · NCI · UNIVERSITY OF MISSOURI-COLUMBIA · PI Jae-Wook Jeong · 2022 to 2026
$2.7M
NCI NIH HHS R01 CA264944
6 · The paper itself

Abstract

Endometrial cancer (EC) is the most common gynecologic malignancy. While the majority of patients present with early-stage and low-grade EC and have an excellent prognosis, a subset has metastatic disease at presentation, or develops distant recurrence after initial treatment of the primary. However, the lack of prognostic biomarkers for metastatic EC is a critical barrier. Arginase 1 (ARG1) regulates the last step of the urea cycle, and an increase in ARG1 has been correlated as a poor prognostic factor in a variety of cancers. In the present study, ARG1 expression was evaluated as a potential prognostic marker for metastatic EC in endometrial hyperplasia and cancer of mice with

Indexed as

ARG1Endometrial CancerMetastasisPTEN

Identifiers

PMID37503068
PMCPMC10371158
OpenAlexW4384697211

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.