ArticleResearch square2023
Prenatal polycyclic aromatic hydrocarbon exposure and asthma at age 8-9 years in a multi-site longitudinal study.
Allison R Sherris, Christine T Loftus, Adam A Szpiro, Logan Dearborn, Marnie F Hazlehurst, Kecia N Carroll, Paul E Moore, Margaret A Adgent, Emily S Barrett, Nicole R Bush and 10 more
Open access · greenAbstract readPreprint
In one paragraphArticle in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 3 citations in OpenAlex.
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
20 authors at 9 institutions in 1 country.
Allison R SherrisUniversity of Washington.
Christine T LoftusUniversity of Washington.
Adam A SzpiroUniversity of Washington.
Logan DearbornUniversity of Washington.
Marnie F HazlehurstUniversity of Washington.
Kecia N CarrollIcahn School of Medicine at Mount Sinai.
Paul E MooreVanderbilt University Medical Center.
Margaret A AdgentVanderbilt University Medical Center.
Emily S BarrettRutgers, The State University of New Jersey.
Nicole R BushUniversity of California, San Francisco.
Drew B DaySeattle Children's Hospital.
Kurunthachalam KannanNew York University.
Kaja Z LeWinnUniversity of California, San Francisco.
Ruby H N NguyenUniversity of Minnesota.
Yu NiUniversity of Washington.
Anne M RiedererUniversity of Washington.
Morgan RobinsonNew York University.
Sheela SathyanarayanaSeattle Children's Hospital.
Qi ZhaoUniversity of Tennessee Health Science Center.
Catherine J KarrUniversity of Washington.
University of Washington · USUniversity of California, San Francisco · USNew York University · USSeattle Children's Hospital · USVanderbilt University Medical Center · USIcahn School of Medicine at Mount Sinai · USRutgers, The State University of New Jersey · USUniversity of Minnesota · USUniversity of Tennessee Health Science Center · US
Funding
Transform Dissemination and Implementation Science in CTSA ProgramsUL1TR002319 · NCATS · UNIVERSITY OF WASHINGTON · PI John K. Amory · 2017 to 2026
$100.0MTranslational Research Support CoreP30ES005022 · NIEHS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI BRIAN T BUCKLEY · 1988 to 2026
$47.4MXENOBIOTIC BIOTRANSFORMATION AND DISPOSITIONP30ES007033 · NIEHS · UNIVERSITY OF WASHINGTON · PI Nicole Ann Errett · 1995 to 2026
$42.5MPrenatal and Early Childhood Pathways To Health: An Integrated Model of Chemical and Social Exposures, Biological Mechanisms, and Sex-Specific Effects on Neurodevelopment and Respiratory OutcomesUH3OD023271 · OD · UNIVERSITY OF WASHINGTON · PI BUSH, NICOLE RENEE, KARR, CATHERINE J · 2018 to 2022
$37.3MBiostatistics, Epidemiologic & Bioinformatic Training in Environmental HealthT32ES015459 · NIEHS · UNIVERSITY OF WASHINGTON · PI June T. Spector · 2009 to 2026
$10.6MTIDES III: Endocrine Disruption, Hormones, and Sex Differences in Adolescent Airway HealthR01ES025169 · NIEHS · SEATTLE CHILDREN'S HOSPITAL · PI Sheela Sathyanarayana · 2015 to 2026
$9.5MPrenatal and Early Childhood Pathways To Health: An Integrated Model of Chemical and Social Exposures, Biological Mechanisms, and Sex-Specific Effects on Neurodevelopment and Respiratory OutcomesUG3OD023271 · OD · UNIVERSITY OF WASHINGTON · PI BUSH, NICOLE RENEE, KARR, CATHERINE J · 2016 to 2017
$5.1MThe Infant Development and the Environmental Study (TIDES)R01ES016863 · NIEHS · UNIVERSITY OF ROCHESTER · PI SWAN, SHANNA H · 2009 to 2014
$4.0MMaternal Traumatic Stress, Oxidative Stress, Antioxidant Exposures, and Child Asthma and Lung FunctionR01HL132338 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CARROLL, KECIA NICOLE, WRIGHT, ROSALIND J · 2017 to 2021
$3.8MPregnancy Folate Status & Early Childhood Respiratory & Atopic Disease OutcomesR01HL109977 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CARROLL, KECIA NICOLE · 2011 to 2015
$3.4MNCATS NIH HHS UL1 TR002319NHLBI NIH HHS R01 HL109977NHLBI NIH HHS R01 HL132338NIEHS NIH HHS P30 ES005022NIEHS NIH HHS P30 ES007033NIEHS NIH HHS R01 ES016863NIEHS NIH HHS R01 ES025169NIEHS NIH HHS T32 ES015459NIH HHS UG3 OD023271NIH HHS UH3 OD023271
6 · The paper itselfAbstract
Background and aim: Studies suggest prenatal exposure to polycyclic aromatic hydrocarbons (PAHs) may influence wheezing or asthma in preschool-aged children. However, the impact of prenatal PAH exposure on asthma and wheeze in middle childhood remain unclear. We investigated these associations in diverse participants from the ECHO PATHWAYS multi-cohort consortium. Methods: We included 1,081 birth parent-child dyads across five U.S. cities. Maternal urinary mono-hydroxylated PAH metabolite concentrations (OH-PAH) were measured during mid-pregnancy. Asthma at age 8-9 years and wheezing trajectory across childhood were characterized by caregiver reported asthma diagnosis and asthma/wheeze symptoms. We used logistic and multinomial regression to estimate odds ratios of asthma and childhood wheezing trajectories associated with five individual OH-PAHs, adjusting for urine specific gravity, various maternal and child characteristics, study site, prenatal and postnatal smoke exposure, and birth year and season in single metabolite and mutually adjusted models. We used multiplicative interaction terms to evaluate effect modification by child sex and explored OH-PAH mixture effects through Weighted Quantile Sum regression. Results: The prevalence of asthma in the study population was 10%. We found limited evidence of adverse associations between pregnancy OH-PAH concentrations and asthma or wheezing trajectories. We observed adverse associations between 1/9-hydroxyphenanthrene and asthma and persistent wheeze among girls, and evidence of inverse associations with asthma for 1-hydroxynathpthalene, which was stronger among boys, though tests for effect modification by child sex were not statistically. Conclusions: In a large, multi-site cohort, we did not find strong evidence of an association between prenatal exposure to PAHs and child asthma at age 8-9 years, though some adverse associations were observed among girls.
Indexed as
asthmachildren’s healthPAHs
Identifiers
PMID37503063
PMCPMC10371133
OpenAlexW4383895619
What OpenQuestion holds
Textmetadata
LicenceCC BY
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