Evidence map›Paper›PMID 37503058›Full record

ArticlebioRxiv : the preprint server for biology2023

Zmiz1 is a novel regulator of lymphatic endothelial cell gene expression and function.

K C Rajan, Nehal R Patel, Anoushka Shenoy, Joshua P Scallan, Mark Y Chiang, Maria J Galazo, Stryder M Meadows

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

K C RajanDepartment of Cell and Molecular Biology, Tulane University, New Orleans, LA.ORCID 0000-0003-1121-3661
Nehal R PatelDepartment of Cell and Molecular Biology, Tulane University, New Orleans, LA.
Anoushka ShenoyDepartment of Cell and Molecular Biology, Tulane University, New Orleans, LA.
Joshua P ScallanMolecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL, United States.
Mark Y ChiangDivision of Hematology-Oncology, Department of Internal Medicine, Medical School, University of Michigan, Ann Arbor, MI.
Maria J GalazoDepartment of Cell and Molecular Biology, Tulane University, New Orleans, LA.
Stryder M MeadowsDepartment of Cell and Molecular Biology, Tulane University, New Orleans, LA.ORCID 0000-0003-0968-7155
Tulane University · USUniversity of Michigan · USUniversity of South Florida · US

Funding

Angiopoietin-2 Signaling Targeted Therapeutics for Arteriovenous MalformationsR01HL163196 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI MARAMBAUD, PHILIPPE, MEADOWS, STRYDER MEDOAH · 2022 to 2025
$2.7M
Stage-specific roles for Zmiz1 in Notch-dependent steps of early T-cell developmentR01AI136941 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHIANG, MARK Y · 2019 to 2023
$2.5M
Pathways Regulating Lymphatic Vessel Permeability and Valve FormationR01HL142905 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI SCALLAN, JOSHUA PAUL · 2019 to 2023
$2.2M
Molecular mechanisms underlying Arteriovenous Malformations associated with HHTR01HL139713 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI MEADOWS, STRYDER MEDOAH · 2018 to 2022
$1.8M
PLEIOTROPIC EFFECTS OF PRORENIN RECEPOR IN COLLECTING DUCT AND INTRARENAL RAS ACTIVATIONR01DK104375 · NIDDK · TULANE UNIVERSITY OF LOUISIANA · PI PRIETO, MINOLFA C · 2014 to 2018
$1.7M
NHLBI NIH HHS R01 HL139713NHLBI NIH HHS R01 HL142905NHLBI NIH HHS R01 HL163196NIAID NIH HHS R01 AI136941NIDDK NIH HHS R01 DK104375
6 · The paper itself

Abstract

Zinc Finger MIZ-Type Containing 1 (Zmiz1), also known as ZIMP10 or RAI17, is a transcription cofactor and member of the Protein Inhibitor of Activated STAT (PIAS) family of proteins. Zmiz1 is critical for a variety of biological processes including vascular development. However, its role in the lymphatic vasculature is unknown. In this study, we utilized human dermal lymphatic endothelial cells (HDLECs) and an inducible, lymphatic endothelial cell (LEC)-specific

Indexed as

ATAC-seqlymphatic endothelial cellsmigrationproliferationProx1RNA-SeqZmiz1

Identifiers

PMID37503058
PMCPMC10370198
OpenAlexW4385174236

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.