ArticleResearch square2023
Dedicated bacterial esterases reverse lipopolysaccharide ubiquitylation to block immune sensing.
Magdalena Szczesna, Yizhou Huang, Rachel E Lacoursiere, Francesca Bonini, Vito Pol, Fulya Koc, Beatrice Ward, Paul P Geurink, Jonathan N Pruneda, Teresa L M Thurston
Open access · greenAbstract readPreprint
In one paragraphArticle in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0cells of the map it votes in
0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 7 citations in OpenAlex.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
10 authors at 3 institutions in 3 countries.
Magdalena SzczesnaDepartment of Infectious Disease, Centre for Bacteriology Resistance Biology, Imperial College London, London, SW7 2AZ, UK.
Yizhou HuangDepartment of Infectious Disease, Centre for Bacteriology Resistance Biology, Imperial College London, London, SW7 2AZ, UK.
Rachel E LacoursiereDepartment of Molecular Microbiology & Immunology, Oregon Health & Science University, Portland, OR 97239, USA.ORCID 0000-0002-3405-2170 Francesca BoniniDepartment of Infectious Disease, Centre for Bacteriology Resistance Biology, Imperial College London, London, SW7 2AZ, UK.
Vito PolDepartment of Cell and Chemical Biology, Leiden University Medical Center, Leiden, the Netherlands.
Fulya KocDepartment of Infectious Disease, Centre for Bacteriology Resistance Biology, Imperial College London, London, SW7 2AZ, UK.ORCID 0009-0002-0538-5694 Beatrice WardDepartment of Infectious Disease, Centre for Bacteriology Resistance Biology, Imperial College London, London, SW7 2AZ, UK.
Paul P GeurinkDepartment of Cell and Chemical Biology, Leiden University Medical Center, Leiden, the Netherlands.
Jonathan N PrunedaDepartment of Molecular Microbiology & Immunology, Oregon Health & Science University, Portland, OR 97239, USA.ORCID 0000-0002-0304-4418 Teresa L M ThurstonDepartment of Infectious Disease, Centre for Bacteriology Resistance Biology, Imperial College London, London, SW7 2AZ, UK.
Imperial College London · GBLeiden University Medical Center · NLOregon Health & Science University · US
Funding
Exploiting bacterial effector proteins to study human ubiquitin signalingR35GM142486 · NIGMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI Jonathan N Pruneda · 2021 to 2026
$2.6MNIGMS NIH HHS R35 GM142486
6 · The paper itselfAbstract
Pathogenic bacteria have evolved diverse mechanisms to counteract cell-autonomous immunity, which otherwise guards both immune and non-immune cells from the onset of an infection
Identifiers
PMID37503018
PMCPMC10371091
OpenAlexW4384038874
What OpenQuestion holds
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