Evidence map›Paper›PMID 37502986›Full record

ArticlebioRxiv : the preprint server for biology2023

Cold temperature induces a TRPM8-independent calcium release from the endoplasmic reticulum in human platelets.

Anastasiia Stratiievska, Olga Filippova, Tahsin Özpolat, Daire Byrne, S Lawrence Bailey, Molly Y Mollica, Jeff Harris, Kali Esancy, Junmei Chen, Ajay K Dhaka and 3 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Anastasiia StratiievskaBloodworks Research Institute, Seattle, WA, USA.
Olga FilippovaBloodworks Research Institute, Seattle, WA, USA.
Tahsin ÖzpolatBloodworks Research Institute, Seattle, WA, USA.
Daire ByrneBloodworks Research Institute, Seattle, WA, USA.
S Lawrence BaileyBloodworks Research Institute, Seattle, WA, USA.
Molly Y MollicaBloodworks Research Institute, Seattle, WA, USA.
Jeff HarrisBloodworks Research Institute, Seattle, WA, USA.
Kali EsancyDepartment of Biological Structure, University of Washington, Seattle, WA, USA.
Junmei ChenBloodworks Research Institute, Seattle, WA, USA.
Ajay K DhakaDepartment of Biological Structure, University of Washington, Seattle, WA, USA.
Nathan J SniadeckiDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA.
José A LópezBloodworks Research Institute, Seattle, WA, USA.
Moritz StollaBloodworks Research Institute, Seattle, WA, USA.
Bloodworks Northwest · USUniversity of Washington · US

Funding

RESEARCH TRAINING IN HEMATOLOGYT32HL007093 · NHLBI · UNIVERSITY OF WASHINGTON · PI Janis L Abkowitz · 1985 to 2026
$13.9M
Molecular and Translational Studies in Hematologic DisordersR35HL145262 · NHLBI · BLOODWORKS · PI LOPEZ, JOSE ARON · 2019 to 2024
$6.5M
Role of TRPM8 in Cold-stored Platelet TransfusionsR01HL153072 · NHLBI · BLOODWORKS · PI STOLLA, MORITZ · 2020 to 2024
$2.6M
Mechanotransduction by Melusin in Cardiac HypertrophyR01HL149734 · NHLBI · UNIVERSITY OF WASHINGTON · PI SNIADECKI, NATHAN JOHN · 2020 to 2023
$2.1M
Identifying new targets in pain, utilizing the novel analgesic AS1R01NS115747 · NINDS · UNIVERSITY OF WASHINGTON · PI DHAKA, AJAY K · 2021 to 2025
$1.8M
Leica SP8 WWL Confocal MicroscopeS10OD016240 · OD · UNIVERSITY OF WASHINGTON · PI CATTERALL, WILLIAM A · 2014 to 2014
$581k
Connecting Sex to Platelet Function after Mechanical ActivationF31HL147462 · NHLBI · UNIVERSITY OF WASHINGTON · PI MOLLICA, MOLLY YEANDEL · 2019 to 2021
$118k
NHLBI NIH HHS F31 HL147462NHLBI NIH HHS R01 HL149734NHLBI NIH HHS R01 HL153072NHLBI NIH HHS R35 HL145262NHLBI NIH HHS T32 HL007093NIH HHS S10 OD016240NINDS NIH HHS R01 NS115747
6 · The paper itself

Abstract

Platelets are sensitive to temperature changes and akin to sensory neurons, are activated by a decrease in temperature. However, the molecular mechanism of this temperature-sensing ability is unknown. Yet, platelet activation by temperature could contribute to numerous clinical sequelae, most importantly to reduced quality of

Identifiers

PMID37502986
PMCPMC10370076
OpenAlexW4384827802

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.