Evidence map›Paper›PMID 37502978›Full record

ArticlebioRxiv : the preprint server for biology2023

Optical Control of G-Actin with a Photoswitchable Latrunculin.

Nynke A Vepřek, Madeline H Cooper, Laura Laprell, Emily Jie-Ning Yang, Sander Folkerts, Ruiyang Bao, Thomas G Oertner, Liza A Pon, J Bradley Zuchero, Dirk H Trauner

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Nynke A VepřekDepartment of Chemistry, New York University, New York, NY 10003, USA.
Madeline H CooperDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
Laura LaprellInstitute for Synaptic Physiology, ZMNH, University Medical Center Hamburg-Eppendorf, D-20251 Hamburg, Germany.
Emily Jie-Ning YangDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Sander FolkertsDepartment of Chemistry, New York University, New York, NY 10003, USA.
Ruiyang BaoDepartment of Chemistry, New York University, New York, NY 10003, USA.
Thomas G OertnerInstitute for Synaptic Physiology, ZMNH, University Medical Center Hamburg-Eppendorf, D-20251 Hamburg, Germany.
Liza A PonDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY 10032, USA.
J Bradley ZucheroDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
Dirk H TraunerDepartment of Chemistry, New York University, New York, NY 10003, USA.
New York University · USColumbia University Irving Medical Center · USStanford University · USUniversität Hamburg · DE

Funding

Tumor Biology and Microenvironment ProgramP30CA013696 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Anil K Rustgi · 1985 to 2026
$115.3M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007365 · NIGMS · STANFORD UNIVERSITY · PI CHUA, KATRIN F · 1985 to 2021
$33.8M
Mitochondrial inheritance and quality controlR35GM122589 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Liza A Pon · 2017 to 2026
$5.1M
Optical Control of the Actin CytoskeletonR01GM126228 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI DIRK HARTWIG TRAUNER · 2018 to 2026
$2.6M
How Does Actin Disassembly Drive Myelin Wrapping?R01NS119823 · NINDS · STANFORD UNIVERSITY · PI ZUCHERO, JOHN B · 2020 to 2024
$2.1M
The Role of Actin in Cellular AgingR33AG051047 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI PON, LIZA A · 2018 to 2020
$1.4M
The Role of Actin in Cellular AgingR21AG051047 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI PON, LIZA A · 2016 to 2017
$427k
NCI NIH HHS P30 CA013696NIA NIH HHS R21 AG051047NIA NIH HHS R33 AG051047NIGMS NIH HHS R01 GM126228NIGMS NIH HHS R35 GM122589NIGMS NIH HHS T32 GM007365NINDS NIH HHS R01 NS119823
6 · The paper itself

Abstract

Actin is one of the most abundant proteins in eukaryotic cells and a key component of the cytoskeleton. A range of small molecules have emerged that interfere with actin dynamics by either binding to polymeric F-actin or monomeric G-actin to stabilize or destabilize filaments or prevent their formation and growth, respectively. Amongst these, the latrunculins, which bind to G-actin and affect polymerization, are widely used as tools to investigate actin-dependent cellular processes. Here, we report a photoswitchable version of latrunculin, termed opto-latrunculin (

Identifiers

PMID37502978
PMCPMC10370057
OpenAlexW4384828354

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.