Evidence map›Paper›PMID 37502950›Full record

ArticlebioRxiv : the preprint server for biology2023

Peripheral death by neglect and limited clonal deletion during physiologic B lymphocyte development.

Mikala JoAnn Willett, Christopher McNees, Sukriti Sharma, Anna Minh Newen, Dylan Pfannenstiel, Thomas Moyer, David Stephany, Iyadh Douagi, Qiao Wang, Christian Thomas Mayer

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 3 countries.

Mikala JoAnn WillettExperimental Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health; Bethesda, MD 20892, USA.
Christopher McNeesExperimental Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health; Bethesda, MD 20892, USA.
Sukriti SharmaExperimental Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health; Bethesda, MD 20892, USA.
Anna Minh NewenExperimental Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health; Bethesda, MD 20892, USA.
Dylan PfannenstielExperimental Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health; Bethesda, MD 20892, USA.
Thomas MoyerFlow Cytometry Section, Research Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Bethesda, MD 20892, USA.
David StephanyFlow Cytometry Section, Research Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Bethesda, MD 20892, USA.
Iyadh DouagiFlow Cytometry Section, Research Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Bethesda, MD 20892, USA.
Qiao WangKey Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Shanghai Institute of Infectious Disease and Biosecurity, School of Basic Medical Sciences, Shanghai Medical College, Fudan University; Shanghai, China, 200032.
Christian Thomas MayerExperimental Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health; Bethesda, MD 20892, USA.
National Institutes of Health · USShanghai Medical College of Fudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autoreactive B cells generated during B cell development are inactivated by clonal deletion, receptor editing or anergy. Up to 97% of immature B cells appear to die before completing maturation, but the anatomic sites and reasons underlying this massive cell loss are not fully understood. Here, we directly quantitated apoptosis and clonal deletion during physiologic B lymphocyte development using Rosa26

Identifiers

PMID37502950
PMCPMC10370189
OpenAlexW4379144183

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.