Evidence map›Paper›PMID 37502947›Full record

ArticlebioRxiv : the preprint server for biology2023

Revealing the combined roles of Aβ and tau in Alzheimer's disease via a pathophysiological activity decoder.

Lazaro M Sanchez-Rodriguez, Gleb Bezgin, Felix Carbonell, Joseph Therriault, Jaime Fernandez-Arias, Stijn Servaes, Nesrine Rahmouni, Cecile Tissot, Jenna Stevenson, Thomas K Karikari and 8 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 8 institutions in 5 countries.

Lazaro M Sanchez-RodriguezDepartment of Neurology and Neurosurgery, McGill University, Montreal, Canada.
Gleb BezginDepartment of Neurology and Neurosurgery, McGill University, Montreal, Canada.
Felix CarbonellBiospective Inc., Montreal, Canada.
Joseph TherriaultDepartment of Neurology and Neurosurgery, McGill University, Montreal, Canada.
Jaime Fernandez-AriasDepartment of Neurology and Neurosurgery, McGill University, Montreal, Canada.
Stijn ServaesDepartment of Neurology and Neurosurgery, McGill University, Montreal, Canada.
Nesrine RahmouniDepartment of Neurology and Neurosurgery, McGill University, Montreal, Canada.
Cecile TissotDepartment of Neurology and Neurosurgery, McGill University, Montreal, Canada.
Jenna StevensonDepartment of Neurology and Neurosurgery, McGill University, Montreal, Canada.
Thomas K KarikariDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
Nicholas J AshtonDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
Andréa L BenedetDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
Henrik ZetterbergDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
Kaj BlennowDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
Gallen Triana-BaltzerNeuroscience Biomarkers, Janssen Research & Development, La Jolla, California, USA.
Hartmuth C KolbNeuroscience Biomarkers, Janssen Research & Development, La Jolla, California, USA.
Pedro Rosa-NetoDepartment of Neurology and Neurosurgery, McGill University, Montreal, Canada.
Yasser Iturria-MedinaDepartment of Neurology and Neurosurgery, McGill University, Montreal, Canada.
Montreal Neurological Institute and Hospital · CAJanssen (United States) · USKing's College London · GBMcGill University · CASahlgrenska University Hospital · SEUniversity of Gothenburg · SEUniversity of Pittsburgh · USUniversity of Wisconsin–Madison · US

Funding

The effects of iron on oxidative stress and Alzheimer's biomarkers in amyloid-positive and negative elderly normalR01AG068398 · NIA · WEILL MEDICAL COLL OF CORNELL UNIV · PI CHIANG, GLORIA CHIA-YI · 2020 to 2024
$2.8M
NIA NIH HHS R01 AG068398
6 · The paper itself

Abstract

Neuronal dysfunction and cognitive deterioration in Alzheimer's disease (AD) are likely caused by multiple pathophysiological factors. However, evidence in humans remains scarce, necessitating improved non-invasive techniques and integrative mechanistic models. Here, we introduce personalized brain activity models incorporating functional MRI, amyloid-β (Aβ) and tau-PET from AD-related participants

Identifiers

PMID37502947
PMCPMC10370127
OpenAlexW4321482306

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.