Evidence map›Paper›PMID 37502884›Full record

ArticlebioRxiv : the preprint server for biology2023

Ventral pallidum GABA and glutamate neurons drive approach and avoidance through distinct modulation of VTA cell types.

Lauren Faget, Lucie Oriol, Wen-Chun Lee, Cody Sargent, Dhakshin Ramanathan, Thomas S Hnasko

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Lauren FagetDepartment of Neurosciences, University of California San Diego, La Jolla, CA 92093, USA.
Lucie OriolDepartment of Neurosciences, University of California San Diego, La Jolla, CA 92093, USA.
Wen-Chun LeeDepartment of Neurosciences, University of California San Diego, La Jolla, CA 92093, USA.
Cody SargentDepartment of Neurosciences, University of California San Diego, La Jolla, CA 92093, USA.
Dhakshin RamanathanDepartment of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA.
Thomas S HnaskoDepartment of Neurosciences, University of California San Diego, La Jolla, CA 92093, USA.
University of California San Diego · US

Funding

Role of novel VTA neurons in addiction-related behaviorsR01DA036612 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Thomas Hnasko · 2014 to 2026
$5.6M
Role of functional and anatomical heterogeneity in ventral pallidum circuits underlying behavioral reinforcementR21MH118748 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HNASKO, THOMAS · 2018 to 2019
$433k
Midbrain neural circuit mechanisms underlying addictionI01BX005782 · VA · VA SAN DIEGO HEALTHCARE SYSTEM · PI HNASKO, THOMAS · 2022 to 2025
–
BLRD VA I01 BX005782NIDA NIH HHS R01 DA036612NIMH NIH HHS R21 MH118748
6 · The paper itself

Abstract

The ventral pallidum (VP) contains GABA and glutamate (Glut) neurons projecting to ventral tegmental area (VTA) whose stimulation drives approach and avoidance, respectively. Yet little is known about the cell-type-specific mechanisms by which VP projections to VTA drive behavior. Here, we found that both VP GABA and Glut neurons were activated during approach to reward or delivery of an aversive stimulus. Stimulation of VP GABA neurons inhibited VTA GABA, but activated dopamine (DA) and glutamate neurons. Remarkably, this cell-type-specific recruitment was behavior-contingent such that VTA recruitment was inhibited when evoked by the subject's own action. Conversely, VP Glut neurons activated VTA GABA, as well as DA and Glut neurons, despite driving aversion. However, VP Glut neurons evoked DA in reward-associated ventromedial nucleus accumbens (NAc), but reduced DA in aversion-associated dorsomedial NAc. These findings show how heterogeneous VP cell types can engage VTA cell types to shape approach and avoidance behaviors.

Identifiers

PMID37502884
PMCPMC10369949
OpenAlexW4384201831

What OpenQuestion holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.