Evidence map›Paper›PMID 37502846›Full record

ArticleResearch square2023

The Piezo channel is central to the mechano-sensitive channel complex in the mammalian inner ear.

Jeong Han Lee, Maria C Perez-Flores, Seojin Park, Hyo Jeong Kim, Yingying Chen, Mincheol Kang, Jennifer Kersigo, Jinsil Choi, Phung N Thai, Ryan Woltz and 14 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

24 authors at 5 institutions in 1 country.

Jeong Han LeeDepartment of Physiology and Cell Biology, School of Medicine, University of Nevada, Reno, NV 89557.
Maria C Perez-FloresDepartment of Physiology and Cell Biology, School of Medicine, University of Nevada, Reno, NV 89557.
Seojin ParkDepartment of Physiology and Cell Biology, School of Medicine, University of Nevada, Reno, NV 89557.
Hyo Jeong KimDepartment of Physiology and Cell Biology, School of Medicine, University of Nevada, Reno, NV 89557.
Yingying ChenDepartment of Physiology and Cell Biology, School of Medicine, University of Nevada, Reno, NV 89557.
Mincheol KangDepartment of Physiology and Cell Biology, School of Medicine, University of Nevada, Reno, NV 89557.
Jennifer KersigoDepartment of Biology, University of Iowa, Iowa City, IA.
Jinsil ChoiDepartment of Physiology and Cell Biology, School of Medicine, University of Nevada, Reno, NV 89557.
Phung N ThaiDivision of Cardiovascular Medicine, Department of Internal Medicine, University of California, Davis, CA 95616.
Ryan WoltzDivision of Cardiovascular Medicine, Department of Internal Medicine, University of California, Davis, CA 95616.
Dolores Columba Perez-FloresDepartment of Physiology and Cell Biology, School of Medicine, University of Nevada, Reno, NV 89557.
Guy PerkinsNational Center for Microscopy and Imaging Research, University of California San Diego, La Jolla, CA 92093.
Choong-Ryoul SihnDepartment of Physiology and Cell Biology, School of Medicine, University of Nevada, Reno, NV 89557.
Pauline TrinhDivision of Cardiovascular Medicine, Department of Internal Medicine, University of California, Davis, CA 95616.
Xiao-Dong ZhangDivision of Cardiovascular Medicine, Department of Internal Medicine, University of California, Davis, CA 95616.
Padmini SirishDivision of Cardiovascular Medicine, Department of Internal Medicine, University of California, Davis, CA 95616.
Yao DongDepartment of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, 1089 VM3B, Davis, CA 95616.
Wayne Wei FengDepartment of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, 1089 VM3B, Davis, CA 95616.
Isaac N PessahDepartment of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, 1089 VM3B, Davis, CA 95616.
Rose E DixonDepartment of Physiology & Membrane Biology, Tupper Hall, One Shields Avenue, Davis, CA. 95616.
Bernd SokolowskiDepartment of Otolaryngology-Head and Neck Surgery, Morsani College of Medicine, University of South Florida, Tampa, FL.
Bernd FritzschDepartment of Biology, University of Iowa, Iowa City, IA.ORCID 0000-0002-4882-8398
Nipavan ChiamvimonvatDivision of Cardiovascular Medicine, Department of Internal Medicine, University of California, Davis, CA 95616.
Ebenezer N YamoahDepartment of Physiology and Cell Biology, School of Medicine, University of Nevada, Reno, NV 89557.
University of California, Davis · USUniversity of Nevada, Reno · USUniversity of California San Diego · USUniversity of Iowa · USUniversity of South Florida · US

Funding

Transgenic Animal Genotyping and Phenotyping CoreP20GM130459 · NIGMS · UNIVERSITY OF NEVADA RENO · PI Nathan Grainger · 2019 to 2026
$20.3M
Structural Analyses CoreP01AG051443 · NIA · UNIVERSITY OF NEVADA RENO · PI RUBIO-VALERO, MARIA-EULALIA · 2016 to 2025
$15.5M
Functional Interactions of Cardiac Ion ChannelsR01HL085844 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHIAMVIMONVAT, NIPAVAN · 2007 to 2025
$7.3M
Translational Study of Cardiac DysfunctionR01HL085727 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHIAMVIMONVAT, NIPAVAN, SIRISH, PADMINI · 2008 to 2022
$5.7M
Inner ear ion channels in healthy and diseased conditionsR01DC016099 · NIDCD · UNIVERSITY OF NEVADA RENO · PI EBENEZER N YAMOAH · 2017 to 2026
$4.7M
Molecular choreography of CaV1.2 channels in the aging myocardiumR01AG063796 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Rose Ellen Dixon · 2019 to 2026
$3.1M
Mechanisms of Growth Factor Responsiveness in the Aging Auditory SystemR01AG060504 · NIA · UNIVERSITY OF NEVADA RENO · PI FRITZSCH, BERND, YAMOAH, EBENEZER N · 2018 to 2022
$2.5M
Lipid regulation of Cardiac Excitation-Contraction couplingR01HL159304 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI DIXON, ROSE ELLEN · 2022 to 2025
$2.4M
Decoding the enigma of cardiac amplificationR01HL137228 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHIAMVIMONVAT, NIPAVAN · 2017 to 2020
$2.2M
Calcium-dependent functions in Hair Cells and Spiral Ganglion NeuronsR01DC015135 · NIDCD · UNIVERSITY OF NEVADA RENO · PI GRATTON, MICHAEL ANNE NMI, YAMOAH, EBENEZER N · 2016 to 2020
$2.1M
Regulation of hair cell functionsR01DC015252 · NIDCD · UNIVERSITY OF NEVADA RENO · PI YAMOAH, EBENEZER N · 2017 to 2021
$2.1M
Cardiac chloride and pH regulation in health and diseaseR01HL158961 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Xiao-Dong Zhang · 2023 to 2026
$1.6M
BLRD VA I01 BX000576CSRD VA I01 CX001490NCRR NIH HHS S10 RR022498NHLBI NIH HHS R01 HL085727NHLBI NIH HHS R01 HL085844NHLBI NIH HHS R01 HL137228NHLBI NIH HHS R01 HL158961NHLBI NIH HHS R01 HL159304NHLBI NIH HHS R56 HL138392NIA NIH HHS P01 AG051443NIA NIH HHS R01 AG060504NIA NIH HHS R01 AG063796NIDCD NIH HHS R01 DC015135NIDCD NIH HHS R01 DC015252NIDCD NIH HHS R01 DC016099NIDCD NIH HHS R01 DC022866NIGMS NIH HHS P20 GM130459
6 · The paper itself

Abstract

The inner ear is the hub where hair cells transduce sound, gravity, and head acceleration stimuli carried by neural codes to the brain. Of all the senses, hearing and balance, which rely on mechanosensation, are the fastest sensory signals transmitted to the central nervous system. The mechanoelectrical transducer (MET) channel in hair cells is the entryway for the sound-balance-brain interface, but the channel's composition has eluded biologists due to its complexity. Here, we report that the mouse utilizes Piezo1 (Pz1) and Piezo2 (Pz2) isoforms as central components of the MET complex. The Pz channel subunits are expressed in hair-cell stereocilia, are co-localized and co-assembled, and are essential components of the MET complex

Identifiers

PMID37502846
PMCPMC10371147
OpenAlexW4384039266

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.