Simplifying the Synthesis of Nonproteinogenic Amino Acids via Palladium-Catalyzed δ-Methyl C-H Olefination of Aliphatic Amines and Amino Acids.

Trisha Bhattacharya, Prabhat Kumar Baroliya, Shaeel A Al-Thabaiti, Debabrata Maiti

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Article in JACS Au, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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Trisha BhattacharyaDepartment of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India.

Prabhat Kumar BaroliyaDepartment of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India.ORCID https://orcid.org/0000-0002-0354-7226

Shaeel A Al-ThabaitiDepartment of Chemistry, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia.

Debabrata MaitiDepartment of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India.ORCID https://orcid.org/0000-0001-8353-1306

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6 · The paper itself

Abstract

Transition metal-catalyzed directing group assisted C-H functionalizations provide a straightforward access to a wide variety of nonproteinogenic amino acids. While altering the side chain of an existing natural amino acids is one way, introducing a functional group to an aliphatic amine to synthesize versatile unnatural amino acids is another exciting avenue. In this work, we explore both the possibilities by the palladium-catalyzed

Identifiers

PMID37502162

DOI10.1021/jacsau.3c00215

PMCPMC10369672

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