ArticleNeurobiology of stress2023
Greater stress and trauma mediate race-related differences in epigenetic age between Black and White young adults in a community sample.
Article in Neurobiology of stress, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 9 citations in OpenAlex.
- The contribution of social and economic factors to accelerated biological aging differences between non-Hispanic Black and White adults in the Health and Retirement Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Placental biology links genetic, epigenetic, ancestral, and social determinants to maternal-fetal health inequities.Frontiers in reproductive health · 2026Review
- From population science to the clinic? Limits of epigenetic clocks as personal biomarkers.Epigenomics · 2025Article
- Cultural mismatch and accelerated epigenetic age during the transition to college.Brain, behavior, & immunity - health · 2025Article
- Accelerated epigenetic ageing after burn injury.GeroScience · 2025Article
- Quantification of Epigenetic Aging in Public Health.Annual review of public health · 2025Review
- Familial Loss of a Loved One and Biological Aging: NIMHD Social Epigenomics Program.JAMA network open · 2024Article
- Racial Discrimination, Neural Connectivity, and Epigenetic Aging Among Black Women.JAMA network open · 2024Article
- Health equity engineering: Optimizing hope for a new generation of healthcare.Journal of clinical and translational science · 2024Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Black Americans suffer lower life expectancy and show signs of accelerated aging compared to other Americans. While previous studies observe these differences in children and populations with chronic illness, whether these pathologic processes exist or how these pathologic processes progress has yet to be explored prior to the onset of significant chronic illness, within a young adult population. Therefore, we investigated race-related differences in epigenetic age in a cross-sectional sample of young putatively healthy adults and assessed whether lifetime stress and/or trauma mediate those differences. Biological and psychological data were collected from self-reported healthy adult volunteers within the local New Haven area (399 volunteers, 19.8% Black, mean age: 29.28). Stress and trauma data was collected using the Cumulative Adversity Inventory (CAI) interview, which assessed specific types of stressors, including major life events, traumatic events, work, financial, relationship and chronic stressors cumulatively over time. GrimAge Acceleration (GAA), determined from whole blood collected from participants, measured epigenetic age. In order to understand the impact of stress and trauma on GAA, exploratory mediation analyses were then used. We found cumulative stressors across all types of events (mean difference of 6.9 p = 2.14e-4) and GAA (β = 2.29 years [1.57-3.01, p = 9.70e-10] for race, partial η
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.