Evidence map›Paper›PMID 37501913›Full record

ArticleEuropean heart journal. Case reports2023

Juvenile-onset multifocal atrial arrhythmias, atrial standstill and compound heterozygosity of genetic variants in

Rachel M A Ter Bekke, Koen de Schouwer, Sergio Conti, Godelieve R F Claes, Jo Vanoevelen, Suzanne Gommers, Apollonia T J M Helderman-van den Enden, Hans-Peter Brunner-LaRocca

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In one paragraph

Article in European heart journal. Case reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Rachel M A Ter BekkeMaastricht University Medical Center (MUMC), Cardiovascular Research Institute Maastricht (CARIM), P. Debyelaan 25, 6229 HX Maastricht, PO box 5800, The Netherlands.ORCID https://orcid.org/0000-0003-4278-0132
Koen de SchouwerDepartment of Cardiology, Cardiovascular Center Onze-Lieve-Vrouwziekenhuis Hospital, Aalst, Belgium.
Sergio ContiDepartment of Cardiac Electrophysiology, ARNAS Civico Hospital, Palermo, Italy.
Godelieve R F ClaesDepartment of Clinical Genetics, Maastricht University Medical Center, Maastricht, The Netherlands.
Jo VanoevelenDepartment of Clinical Genetics, Maastricht University Medical Center, Maastricht, The Netherlands.ORCID https://orcid.org/0000-0003-1830-8858
Suzanne GommersDepartment of Radiology and Nuclear Medicine, Maastricht University Medical Center, Maastricht, The Netherlands.
Apollonia T J M Helderman-van den EndenDepartment of Clinical Genetics, Maastricht University Medical Center, Maastricht, The Netherlands.
Hans-Peter Brunner-LaRoccaMaastricht University Medical Center (MUMC), Cardiovascular Research Institute Maastricht (CARIM), P. Debyelaan 25, 6229 HX Maastricht, PO box 5800, The Netherlands.
Maastricht University · NLAzienda di Rilievo Nazionale ed Alta Specializzazione · ITOnze Lieve Vrouwziekenhuis Hospital · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Juvenile onset of extensive atrial electromechanical failure, including atrial standstill, is a rare disease entity that may precede ventricular cardiomyopathy. Genetic variants associated with early-onset atrioventricular (AV) cardiomyopathy are increasingly recognized. Case summary: A 16-year-old patient presented with atrial brady- and tachyarrhythmias and concomitant impaired atrial electromechanical function (atrial standstill). The atrial phenotype preceded the development of a predominantly right-sided AV dilated cardiomyopathy with pronounced myocardial fibrosis. A His-bundle pacemaker was installed for high-degree AV conduction block and sinus arrest. Using familial-based whole-exome sequencing, a missense mutation and a copy number variant deletion (compound heterozygosity) of the Discussion: Juvenile onset of severe atrial electromechanical failure with atrial arrhythmias should prompt deep pheno- and genotyping and calls for vigilance for downstream cardiomyopathic deterioration.

Indexed as

Atrial standstillCase reportDilated cardiomyopathyMultifocal atrial arrhythmiasTAF1A

Identifiers

PMID37501913
PMCPMC10371049
OpenAlexW4379880714

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.