Evidence map›Paper›PMID 37501576›Full record

ArticleChemistry & biodiversity2023

Synthesis of Novel Pyrazole-Oxindole Conjugates with Cytotoxicity in Human Cancer Cells via Apoptosis.

Pravesh M Jain, Denisse A Gutierrez, Sujeet Kumar, Renato J Aguilera, Subhas S Karki

Open access · greenAbstract read
In one paragraph

Article in Chemistry & biodiversity, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Pravesh M JainDepartment of Pharmaceutical Chemistry, KLE College of Pharmacy (A Constituent Unit of KLE Academy of Higher Education & Research-Belagavi), Rajajinagar, Bengaluru, Karnataka, India-, 560010.
Denisse A GutierrezCellular Characterization and Biorepository Core Facility, Border Biomedical Research Center, Department of Biological Sciences, College of Science, The University of Texas at El Paso, 500 West University Avenue, El Paso, TX 79968-0519, USA.ORCID http://orcid.org/0000-0001-5421-2242
Sujeet KumarDepartment of Pharmaceutical Chemistry, KLE College of Pharmacy (A Constituent Unit of KLE Academy of Higher Education & Research-Belagavi), Rajajinagar, Bengaluru, Karnataka, India-, 560010.ORCID http://orcid.org/0000-0002-0833-158X
Renato J AguileraCellular Characterization and Biorepository Core Facility, Border Biomedical Research Center, Department of Biological Sciences, College of Science, The University of Texas at El Paso, 500 West University Avenue, El Paso, TX 79968-0519, USA.ORCID http://orcid.org/0000-0003-3765-2793
Subhas S KarkiDepartment of Pharmaceutical Chemistry, KLE College of Pharmacy (A Constituent Unit of KLE Academy of Higher Education & Research-Belagavi), Rajajinagar, Bengaluru, Karnataka, India-, 560010.ORCID http://orcid.org/0000-0002-5599-3594
Health First · USThe University of Texas at El Paso · USKLE University · IN

Funding

UTEP Border Biomedical Research CenterU54MD007592 · NIMHD · UNIVERSITY OF TEXAS EL PASO · PI ARSHAD M. KHAN · 2019 to 2026
$35.1M
TCCG12MD007592 · NIMHD · UNIVERSITY OF TEXAS EL PASO · PI KIRKEN, ROBERT A. · 2012 to 2018
$19.4M
UTEP SCORE InstrumentationS06GM008012 · NIGMS · UNIVERSITY OF TEXAS EL PASO · PI ZHANG, JIANYING · 1989 to 2010
$15.8M
Characterization of novel pyrazole compounds with potent anti-cancer activityR16GM149379 · NIGMS · UNIVERSITY OF TEXAS EL PASO · PI RENATO J AGUILERA · 2023 to 2026
$605k
NIGMS NIH HHS R16 GM149379NIGMS NIH HHS S06 GM008012NIMHD NIH HHS G12 MD007592NIMHD NIH HHS U54 MD007592
6 · The paper itself

Abstract

A novel series of pyrazole-oxindole conjugates were prepared and characterized as potential cytotoxic agents by FT-IR, NMR and HR-MS. The cytotoxic activity of these compounds was tested in the Jurkat acute T cell leukemia, CEM acute lymphoblastic leukemia, MCF10 A mammary epithelial and MDA-MB 231 triple negative breast cancer cell lines. Among the tested conjugates, 5-methyl-3-((3-(1-phenyl)-3-(p-tolyl)-1H-pyrazol-4-yl)methylene)indolin-2-one 6h emerged as the most cytotoxic with a CC

Indexed as

Antineoplastic AgentsNeoplasmsApoptosisCell Line, TumorHumansOxindolesPyrazolesReactive Oxygen SpeciesSpectroscopy, Fourier Transform InfraredAntineoplastic AgentsOxindolesPyrazolesReactive Oxygen Speciesanticancerapoptosiscell cyclecytotoxicitypyrazole-oxindole

Identifiers

PMID37501576
PMCPMC10938640
OpenAlexW4385330719

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.