Evidence map›Paper›PMID 37501150›Full record

ArticleJournal of ovarian research2023

Ovarian reserve in women with cystic fibrosis: is this a cause of sub-fertility?

Malena Cohen-Cymberknoh, Keren Marks Garber, Joel Reiter, Michal Shteinberg, Aielet Stolovas, Iyad Barghouti, Chana Adler Lazarovits, Efrat Esh Broder, Anat Hershko Klement

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of ovarian research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 70% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Malena Cohen-Cymberknoh *Pediatric Pulmonary Unit and Cystic Fibrosis Center, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
Keren Marks Garber *The IVF Unit, Mount Scopus, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
Joel ReiterPediatric Pulmonary Unit and Cystic Fibrosis Center, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
Michal ShteinbergPulmonology Institute and Cystic Fibrosis Center, Carmel Medical Center and Technion- Israel Institute of Technology and the B. Rappaport Faculty of Medicine, Haifa, Israel.
Aielet StolovasPediatric Pulmonary Unit and Cystic Fibrosis Center, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
Iyad BarghoutiBiochemistry Laboratory, Hadassah Medical Center, Mount Scopus, Jerusalem, Israel.
Chana Adler LazarovitsThe IVF Unit, Mount Scopus, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
Efrat Esh BroderThe IVF Unit, Mount Scopus, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
Anat Hershko KlementThe IVF Unit, Mount Scopus, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel. anat.klement@gmail.com.
Hebrew University of Jerusalem · ILHadassah Medical Center · ILTechnion – Israel Institute of Technology · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOver the past two decades, increasing number of people with cystic fibrosis (CF) survive into adulthood. Compared to the general population, sub-fertility is an obstacle for many women with CF (wwCF). Decreased ovarian reserve has been proposed as a possible cause, but limited data is available to support this. The aim of this study was to evaluate the ovarian reserve in wwCF and to correlate this with patients' demographic and clinical data.

methodsReproductive-aged wwCF were enrolled during their routine medical appointments. Assessment included Anti-Mullerian hormone (AMH) levels, routine blood tests and antral follicular count (AFC) evaluation. Additionally, demographic, and clinical information were collected.

resultsA total of wenty-three wwCF were enrolled, with ages ranging from 19 to 40 years (median 27 years). Among the fourteen wwCF who were considering pregnancy, five (35.7%) disclosed undergoing an infertility assessment and receiving fertility treatments. All but one patient had an Anti-Mullerian hormone (AMH) level between the 5th and 95th % for age. Measurement of the antral follicular count (AFC) was possible in 12 of the 23 patients and was ranging 8-40 with a median of 17. The proportion of wwCF presenting below median AMH values was not different in sub-fertile as compared to fertile wwCF (P value 0.54). There were no correlations between AMH levels and disease severity parameters. AMH seemed to be relatively higher in wwCF with mild class mutations, but this was not shown to have statistical significance.

conclusionsOur results, in contrast with the limited available published data, do not support the hypothesis that decreased ovarian reserve plays a major role in infertility in wwCF.

Indexed as

Cystic FibrosisInfertilityOvarian ReserveAdultAnti-Mullerian HormoneFemaleHumansOvarian FolliclePregnancyAnti-Mullerian HormoneAnti-mullerian hormoneCystic fibrosisInfertilityOvarian folliclesOvarian reserveSubfertility

Identifiers

PMID37501150
PMCPMC10375728
OpenAlexW4385302352

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.