ArticleThe journal of headache and pain2023
2:1 ketogenic diet and low-glycemic-index diet for the treatment of chronic and episodic migraine: a single-center real-life retrospective study.
Article in The journal of headache and pain, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Risk factors associated to disability in primary headaches: a systematic review to inform future iterations of the Global Burden of Disease Study.The journal of headache and pain · 2025Pooled it
- Dietary Modulation of Migraine: Metabolic, Neuroinflammatory and Microbiota-Mediated Mechanisms.Journal of clinical medicine · 2026Review
- The microgenderome in migraine: integrating sex hormones, microbial composition, and metabolic profiles into a sex-related framework.Frontiers in microbiology · 2026Review
- The Hypometabolic State of the Migraine Brain: Is a Ketogenic Diet the Answer?Brain and behavior · 2025Review
- Forecasting migraine attacks by managing daily lifestyle: a systematic review as a basis to develop predictive algorithms.Pain reports · 2025Article
- Fasting and Headache.Current pain and headache reports · 2025Review
- The Interplay Between Gut Microbiota, Adipose Tissue, and Migraine: A Narrative Review.Nutrients · 2025Review
- Energy metabolism disorders in migraine: triggers, pathways, and therapeutic repurposing.Frontiers in neurology · 2025Review
- Ketogenic Diet Improves Sleep Quality and Daytime Sleepiness in Chronic Migraine: A Pilot Study.Neurology international · 2024Article
- The Brain, the Eating Plate, and the Gut Microbiome: Partners in Migraine Pathogenesis.Nutrients · 2024Review
- A 1-month ketogenic diet in patients with migraine gives a clinical beneficial effect associated with increased latency of somatosensory thalamo-cortical activity.Clinical neurophysiology practice · 2024Article
- Specifically formulated ketogenic, low carbohydrate, and carnivore diets can prevent migraine: a perspective.Frontiers in nutrition · 2024Article
- The Effect of Three Different Ketogenic Diet Protocols on Migraine and Fatigue in Chronic and High-Frequency Episodic Migraine: A Pilot Study.Nutrients · 2023Article
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsThe evidence supporting the efficacy of dietary preventive therapy in migraine is rising, particularly regarding the ketogenic diet. However, less evidence exists for the Low-Glycemic Index Diet and the 2:1 KD. This retrospective single-center real-life study aims to evaluate the efficacy of a 2:1 ketogenic diet and a Low-Glycemic-index Diet in chronic and high-frequency episodic migraine.
methodsSixty patients with high-frequency episodic and chronic migraine were treated with either a Low-Glycemic-index diet (39 patients) or a 2:1 (21 patients) ketogenic diet for three months. We collected data on the migraine frequency and intensity and the MIDAS and HIT-6 scores through the headache diary. Anthropometric measurements (BMI, fat mass, free fat mass, and weight) were also collected and analyzed similarly. Data obtained at the baseline and after three months of each diet were compared.
resultsMigraine intensity, frequency, MIDAS and HIT-6 scores, fat mass, weight, and BMI improved in both diet groups.
conclusionsBoth diets are effective in reducing migraine symptoms and migraine-related disability.
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