Evidence map›Paper›PMID 37501090›Full record

ReviewExperimental hematology & oncology2023

Multidisciplinary recommendations for the management of CAR-T recipients in the post-COVID-19 pandemic era.

Tingting Zhang, Weiwei Tian, Shuang Wei, Xinyi Lu, Jing An, Shaolong He, Jie Zhao, Zhilin Gao, Li Li, Ke Lian and 26 more

Open access · goldAbstract readReview
In one paragraph

Review in Experimental hematology & oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
7.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

36 authors at 16 institutions in 1 country.

Tingting Zhang *Cancer Center, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, 030032, Shanxi, China.
Weiwei Tian *Department of Hematology, Tongji Shanxi Hospital, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Taiyuan, 030032, Shanxi, China.
Shuang Wei *Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China.
Xinyi LuDepartment of Hematology, Tongji Shanxi Hospital, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Taiyuan, 030032, Shanxi, China.
Jing AnSchool of Public Health, Shanxi Medical University, Taiyuan, 030000, Shanxi, China.
Shaolong HeDepartment of Hematology, Tongji Shanxi Hospital, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Taiyuan, 030032, Shanxi, China.
Jie ZhaoDepartment of Hematology, Tongji Shanxi Hospital, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Taiyuan, 030032, Shanxi, China.
Zhilin GaoDepartment of Hematology, Tongji Shanxi Hospital, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Taiyuan, 030032, Shanxi, China.
Li LiCancer Center, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, 030032, Shanxi, China.
Ke LianCancer Center, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, 030032, Shanxi, China.
Qiang ZhouDivision of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China.
Huilai ZhangDepartment of Lymphoma, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, 300060, China.
Liang WangDepartment of Hematology, Beijing TongRen Hospital, Capital Medical University, Beijing, 100730, China.
Liping SuShanxi Province Cancer Hospital, Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences, Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan, 030032, Shanxi, China.
Huicong KangDepartment of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China.
Ting NiuDepartment of Hematology, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
Ailin ZhaoDepartment of Hematology, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
Jing PanState Key Laboratory of Experimental Hematology, Boren Biotherapy Translational Laboratory, Boren Clinical Translational Center, Beijing GoBroad Boren Hospital, Beijing, 100070, China.
Qingqing CaiSun Yat-Sen University Cancer Center, Guangzhou, 510060, Guangdong, China.
Zhenshu XuHematology Department, Fujian Medical University Union Hospital, Fujian Institute of Hematology, Fuzhou, 350001, Fujian, China.
Wenming ChenDepartment of Hematology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, 100020, China.
Hongmei JingDepartment of Hematology, Peking University Third Hospital, Beijing, 100191, China.
Peng LiGuangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510535, Guangdong, China.
Wanhong ZhaoDepartment of Hematology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, Shanxi, China.
Yang CaoDepartment of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China.
Jianqing MiShanghai Institute of Hematology, Ruijin Hospital Affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Tao ChenDepartment and Institute of Infectious Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China.
Yuan ChenDepartment of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China.
Ping ZouInstitute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, Hubei, China.
Veronika Lukacs-KornekInstitute of Molecular Medicine and Experimental Immunology, University Clinic of Rheinische Friedrich-Wilhelms-University, 53111, Bonn, Germany.
Christian KurtsInstitute of Molecular Medicine and Experimental Immunology, University Clinic of Rheinische Friedrich-Wilhelms-University, 53111, Bonn, Germany.
Jian LiInstitute of Molecular Medicine and Experimental Immunology, University Clinic of Rheinische Friedrich-Wilhelms-University, 53111, Bonn, Germany.
Xiansheng LiuDepartment of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China. xsliu@tjh.tjmu.edu.cn.
Qi MeiSino-German Joint Oncological Research Laboratory, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Taiyuan, 030032, Shanxi, China. borismq@163.com.
Yicheng ZhangDepartment of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China. yczhang@tjh.tjmu.edu.cn.
Jia WeiDepartment of Hematology, Tongji Shanxi Hospital, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Taiyuan, 030032, Shanxi, China. jiawei@tjh.tjmu.edu.cn.
Shanxi Medical University · CNShanxi Academy of Medical Sciences · CNTongji Hospital · CNHuazhong University of Science and Technology · CNWest China Hospital of Sichuan University · CNBeijing Chao-Yang Hospital · CNCapital Medical University · CNFujian Medical University · CNGuangzhou Institutes of Biomedicine and Health · CNHubei Provincial Center for Disease Control and Prevention · CNPeking University · CNSecond Affiliated Hospital of Xi'an Jiaotong University · CNShanghai Jiao Tong University · CNSun Yat-sen University Cancer Center · CNTianjin Medical University Cancer Institute and Hospital · CNUnion Hospital · CN

Funding

2023 COVID-19 Emergency Project of Shanxi Bethune Hospital 2023xg022023 COVID-19 Emergency Project of Shanxi Bethune Hospital 2023xg05-22023 COVID-19 Emergency Project of Shanxi Health Commission 2023XG0012023 COVID-19 Emergency Project of Shanxi Health Commission 2023XG005National High Technology Research and Development Program of China 2021YFA1101504National Natural Science Foundation of China 82070217National Natural Science Foundation of China 82270175Natural Science Foundation of Fujian Province of China 2021J02040Sino-German Center for Research Promotion (SGC)'s rapid Response Funding for Bilateral Collaborative Proposals Between China and Germany in COVID-19 Related Research C-0065
6 · The paper itself

Abstract

The outbreak of coronavirus disease 2019 (COVID-19) posed an unprecedented challenge on public health systems. Despite the measures put in place to contain it, COVID-19 is likely to continue experiencing sporadic outbreaks for some time, and individuals will remain susceptible to recurrent infections. Chimeric antigen receptor (CAR)-T recipients are characterized by durable B-cell aplasia, hypogammaglobulinemia and loss of T-cell diversity, which lead to an increased proportion of severe/critical cases and a high mortality rate after COVID-19 infection. Thus, treatment decisions have become much more complex and require greater caution when considering CAR T-cell immunotherapy. Hence, we reviewed the current understanding of COVID-19 and reported clinical experience in the management of COVID-19 and CAR-T therapy. After a panel discussion, we proposed a rational procedure pertaining to CAR-T recipients with the aim of maximizing the benefit of CAR-T therapy in the post COVID-19 pandemic era.

Indexed as

CAR T-cellCOVID-19Hematological malignanciesRecommendationsSARS-CoV-2Treatment

Identifiers

PMID37501090
PMCPMC10375673
OpenAlexW4385303941

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.