Evidence map›Paper›PMID 37501045›Full record

ArticleMolecular biology reports2023

The expression levels of PPAR-α/γ and UCP1/2 on the slow coronary flow phenomenon; results from a case-control study.

Mahshid Ghodrat, Ahmad Separham, Erfan Banisefid, Naimeh Mesri Alamdari, Moloud Akbarzadeh, Shahriar Alipour, Tohid Yahyapoor, Neda Roshanravan, Samad Ghaffari

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Article in Molecular biology reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Mahshid GhodratCardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, 5166615573, Iran.ORCID https://orcid.org/0009-0001-9553-3752
Ahmad SeparhamCardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, 5166615573, Iran.
Erfan BanisefidStudents Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.ORCID http://orcid.org/0000-0001-7825-2759
Naimeh Mesri AlamdariEndocrine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.ORCID http://orcid.org/0000-0003-2563-8193
Moloud AkbarzadehCentre de Recherche de L'Institut Universitaire de Cardiologie Et de Pneumologie de Québec (CRIUCPQ), Faculté de Médecine, Université Laval, Québec, QC, Canada.ORCID http://orcid.org/0000-0002-6073-7624
Shahriar AlipourCellular and Molecular Research Center, Cellular and Molecular Medicine Institute, Urmia University of Medical Sciences, Urmia, Iran.ORCID http://orcid.org/0000-0002-2202-9598
Tohid YahyapoorCardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, 5166615573, Iran.ORCID http://orcid.org/0000-0002-7530-0468
Neda RoshanravanCardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, 5166615573, Iran. neda.roshanravan10@gmail.com.ORCID http://orcid.org/0000-0002-8173-6532
Samad GhaffariCardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, 5166615573, Iran. ghafaris@gmail.com.ORCID http://orcid.org/0000-0001-6806-9387
Tabriz University of Medical Sciences · IRInstitut universitaire de cardiologie et de pneumologie de Québec · CAUrmia University · IR

Funding

Tabriz University of Medical Sciences 62278
6 · The paper itself

Abstract

purposeThe slow coronary flow (SCF) phenomenon is considered a coronary artery disorder. Because of the critical function of peroxisome proliferator-activated receptors (PPARs) in regulating the oxidative stress and inflammatory reactions in cardiovascular disease, The aim of the current study was to investigate the expression of the genes for uncoupling proteins 1 and 2 (UCP1 and UCP2), peroxisome proliferator-activated receptors and (PPAR- PPAR-), and PPAR- in SCF patients.

methodsIn this case-control study, coronary angiography examination was used to analyze 35 individuals with SCF and 35 subjects with normal coronary flow (NCF). SCF was diagnosed using the TIMI (thrombolysis in myocardial infarction frame count) method. The SCF phenomenon is thought to be the TIMI > 27. In the peripheral blood mononuclear cells (PBMCs), the messenger ribonucleic acid (mRNA) expression levels of the PPAR-, PPAR-, UCP1, and UCP2 genes were evaluated.

resultsUCP1 and UCP2 expression levels were significantly higher in the SCF group compared to the NCF group (P = 0.034 and P0.001, respectively). The PPAR- and PPAR- levels were found to be significantly lower in the SCF group compared to the NCF group (P = 0.015, P0.001, respectively). According to the results of the logistic regression analysis, high UCP1 and UCP2 levels and low PPAR- and PPAR- levels are each independent predictors of the SCF phenomenon.

conclusionThis research provided evidence about the potential role of PPAR-α, PPAR-γ, UCP1, and UCP2 as biomarkers in SCF. More investigations are suggested to assess the functions of these factors in SCF patients mechanistically.

Indexed as

Coronary Artery DiseaseCoronary CirculationCase-Control StudiesCoronary AngiographyCoronary VesselsHumansLeukocytes, MononuclearPPAR gammaUncoupling Protein 1PPAR gammaUCP1 protein, humanUncoupling Protein 1PPAR-αPPAR-γReactive oxygen speciesSlow coronary flowUCP1UCP2

Identifiers

PMID37501045
OpenAlexW4385302560

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.