ArticleNature aging2023
Olfactory chemosensation extends lifespan through TGF-β signaling and UPR activation.
Article in Nature aging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 39 citations in OpenAlex.
- Proteostasis Rebalancing by LET-607 Deficiency Promotes Longevity.Aging cell · 2026Article
- Reduced gravity and muon flux absence affectMicrobiology spectrum · 2026Article
- Gas-sensing neurons prime mitochondrial fitness to offset metabolic stress.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Adaptive inter-tissue proteostasis networks in aging and neurodegeneration.Bioscience reports · 2026Review
- A nose-to-brain axis for spoiled food odor-triggered defensive responses in male mice.Nature communications · 2026Article
- Intersections between proteostasis and immunity: insights from Caenorhabditis elegans.Disease models & mechanisms · 2026Review
- Volatile and non-volatile pathogen cues shape host extracellular vesicles production in pre-infection response.Nature communications · 2025Article
- Distinct responses to non-autonomous UPRCommunications biology · 2025Article
- Environmental stress promotes the persistence of juvenile traits in olfactory neurons as a protective mechanism.iScience · 2025Article
- Identification of genetic signatures of positive selection in apes linked to life-history trait adaptations.Genes & genomics · 2025Article
- Modulation of C. elegans behavior, fitness, and lifespan by AWB/ASH-dependent death perception.Current biology : CB · 2025Article
- Maral Root Extract and Its Main Constituent 20-Hydroxyecdysone Enhance Stress Resilience inInternational journal of molecular sciences · 2025Article
- Article
- Perception and Longevity Control in Invertebrate Model Organisms-A Mini-Review of Recent Advances.Biomolecules · 2025Review
- Histone mark age of human tissues and cell types.Science advances · 2025Article
- A nucleolar mechanism suppresses organismal proteostasis by modulating TGFβ/ERK signalling.Nature cell biology · 2025Article
- Neuronal PRDX-2-Mediated ROS Signaling Regulates Food Digestion via peripheral UPRNature communications · 2024Article
- ASI-RIM neuronal axis regulates systemic mitochondrial stress response via TGF-β signaling cascade.Nature communications · 2024Article
- Pseudomonas aeruginosa modulates both Caenorhabditis elegans attraction and pathogenesis by regulating nitrogen assimilation.Nature communications · 2024Article
- Role of the central nervous system in cell non-autonomous signaling mechanisms of aging and longevity in mammals.The journal of physiological sciences : JPS · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Animals rely on chemosensory cues to survive in pathogen-rich environments. In Caenorhabditis elegans, pathogenic bacteria trigger aversive behaviors through neuronal perception and activate molecular defenses throughout the animal. This suggests that neurons can coordinate the activation of organism-wide defensive responses upon pathogen perception. In this study, we found that exposure to volatile pathogen-associated compounds induces activation of the endoplasmic reticulum unfolded protein response (UPR
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.