Evidence map›Paper›PMID 37500914›Full record

ArticleNature biotechnology2024

Generation of accurate, expandable phylogenomic trees with uDance.

Metin Balaban, Yueyu Jiang, Qiyun Zhu, Daniel McDonald, Rob Knight, Siavash Mirarab

Erratum issuedAbstract read
In one paragraph

Article in Nature biotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Deconvolving Phylogenetic Distance Mixtures.bioRxiv : the preprint server for biology · 2026
    Article
  5. Article
  6. Article
  7. The evolution of the tree of life.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Article
  8. Chance and purpose in the evolution of biospheres.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Article
  9. Accurate, scalable, and fully automated inference of species trees from raw genome assemblies using ROADIES.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  10. Article
  11. Memory-boundGenome research · 2024
    Article
  12. Article
  13. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Metin BalabanBioinformatics and Systems Biology Graduate Program, University of California San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-6947-5915
Yueyu JiangDepartment of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, USA.
Qiyun ZhuBiodesign Center for Fundamental and Applied Microbiomics, Arizona State University, Tempe, AZ, USA.ORCID http://orcid.org/0000-0002-3568-6271
Daniel McDonaldDepartment of Pediatrics, University of California San Diego, La Jolla, CA, USA.
Rob KnightDepartment of Pediatrics, University of California San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-0975-9019
Siavash MirarabDepartment of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, USA. smirarab@ucsd.edu.ORCID http://orcid.org/0000-0001-5410-1518

Funding

National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)U24AG021886 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI TATIANA M. FOROUD · 2002 to 2026
$119.8M
Project 4 - Mechanistic studies on the role of the gut microbiome in models for Alzheimer's diseaseU19AG063744 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Rima F Kaddurah-Daouk · 2019 to 2026
$54.1M
The UCSD Microbiome and Metagenomics Center (Summit Supplement)U24DK131617 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jack Anthony Gilbert, ROB KNIGHT · 2022 to 2026
$15.3M
Mapping host-microbe-metabolite interactions in 3D to find diet-derived enhancers of immunityDP1AT010885 · NCCIH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KNIGHT, ROB · 2019 to 2023
$5.5M
Biology-aware machine learning methods for characterizing microbiome genotype and phenotypeR35GM142725 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MIR ARABBAYGI, SIAVASH · 2021 to 2025
$1.9M
National Science Foundation (NSF) BIO21010National Science Foundation (NSF) CI-1548562National Science Foundation (NSF) IIS 1845967National Science Foundation (NSF) RAPID 20385.09NCCIH NIH HHS DP1 AT010885NIA NIH HHS U19 AG063744NIA NIH HHS U24 AG021886NIDDK NIH HHS U24 DK131617NIGMS NIH HHS R35 GM142725U.S. Department of Health & Human Services | National Institutes of Health (NIH) DP1-AT010885U.S. Department of Health & Human Services | National Institutes of Health (NIH) R35GM142725U.S. Department of Health & Human Services | National Institutes of Health (NIH) U19AG063744U.S. Department of Health & Human Services | National Institutes of Health (NIH) U24DK131617
6 · The paper itself

Abstract

Phylogenetic trees provide a framework for organizing evolutionary histories across the tree of life and aid downstream comparative analyses such as metagenomic identification. Methods that rely on single-marker genes such as 16S rRNA have produced trees of limited accuracy with hundreds of thousands of organisms, whereas methods that use genome-wide data are not scalable to large numbers of genomes. We introduce updating trees using divide-and-conquer (uDance), a method that enables updatable genome-wide inference using a divide-and-conquer strategy that refines different parts of the tree independently and can build off of existing trees, with high accuracy and scalability. With uDance, we infer a species tree of roughly 200,000 genomes using 387 marker genes, totaling 42.5 billion amino acid residues.

Indexed as

PhylogenyAlgorithmsEvolution, MolecularGenomicsSoftware

Identifiers

PMID37500914
PMCPMC10818028

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.