Evidence map›Paper›PMID 37500886›Full record

ArticleNature immunology2023

Apoptotic contraction drives target cell release by cytotoxic T cells.

Elisa E Sanchez, Maria Tello-Lafoz, Aixuan J Guo, Miguel de Jesus, Yassmin A Elbanna, Benjamin Y Winer, Sadna Budhu, Eric Chan, Eric Rosiek, Taisuke Kondo and 5 more

Open access · greenAbstract read
In one paragraph

Article in Nature immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Mechanoregulation of lymphocyte cytotoxicity.Nature reviews. Immunology · 2025
    Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 2 countries.

Elisa E SanchezImmunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Maria Tello-LafozImmunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0001-8909-6800
Aixuan J GuoImmunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Miguel de JesusImmunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-9706-7249
Yassmin A ElbannaImmunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Benjamin Y WinerImmunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Sadna BudhuDepartment of Pharmacology, Weill-Cornell Medical College, New York, NY, USA.
Eric ChanMolecular Cytology Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Eric RosiekMolecular Cytology Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Taisuke KondoCenter for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
Justyn DuSoldCenter for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
Naomi TaylorCenter for Cancer Research, National Cancer Institute, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-2459-4558
Gregoire Altan-BonnetCenter for Cancer Research, National Cancer Institute, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-7283-3162
Michael F OlsonDepartment of Chemistry and Biology, Toronto Metropolitan University, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0003-3428-3507
Morgan HuseImmunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. husem@mskcc.org.ORCID http://orcid.org/0000-0001-9941-7719
Memorial Sloan Kettering Cancer Center · USNational Cancer Institute · USCornell University · USToronto Metropolitan University · CA

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Synaptic Control of Cytotoxic T cell FunctionR01AI087644 · NIAID · SLOAN-KETTERING INST CAN RESEARCH · PI HUSE, MORGAN A · 2010 to 2025
$7.3M
Architectural regulation of cytotoxic synapse detachmentR21AI169847 · NIAID · SLOAN-KETTERING INST CAN RESEARCH · PI HUSE, MORGAN A · 2022 to 2023
$487k
NCI NIH HHS P30 CA008748NIAID NIH HHS R01 AI087644NIAID NIH HHS R21 AI169847
6 · The paper itself

Abstract

Cytotoxic T lymphocytes (CTLs) fight intracellular pathogens and cancer by identifying and destroying infected or transformed target cells

Indexed as

ApoptosisT-Lymphocytes, CytotoxicGranzymesPerforinGranzymesPerforin

Identifiers

PMID37500886
PMCPMC11138163
OpenAlexW4385330997

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.