ArticleNature microbiology2023
A predicted CRISPR-mediated symbiosis between uncultivated archaea.
Article in Nature microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 20 citations in OpenAlex.
- Responses of Groundwater Bacterial Communities to Extreme Rainfall in the Western North China Plain Based on 16S rRNA Sequencing.Microorganisms · 2026Article
- Horizontal gene transfer and gene loss drove the divergent evolution of host dependency in Micrarchaeota.National science review · 2026Article
- A genomic view of Earth's biomes.Nature reviews. Genetics · 2026Review
- Biogeography and host interactions of CPR and DPANN viruses in acid mine drainage sediments.Nature communications · 2025Article
- Viruses and virus satellites of haloarchaea and their nanosized DPANN symbionts reveal intricate nested interactions.Nature microbiology · 2025Article
- Acquisition of Spacers from Foreign Prokaryotic Genomes by CRISPR-Cas Systems in Natural Environments.Genome biology and evolution · 2025Article
- Phylogenomic analyses indicate the archaeal superphylum DPANN originated from free-living euryarchaeal-like ancestors.Nature microbiology · 2025Article
- Differential Expression of Core Metabolic Functions in Candidatus Altiarchaeum Inhabiting Distinct Subsurface Ecosystems.Environmental microbiology reports · 2025Article
- Metagenomic characterization of viruses and mobile genetic elements associated with the DPANN archaeal superphylum.Nature microbiology · 2024Article
- Lineage-dependent partitioning of activities in chemoclines defines Woesearchaeota ecotypes in an extreme aquatic ecosystem.Microbiome · 2024Article
- Cell-to-cell interactions revealed by cryo-tomography of a DPANN co-culture system.Nature communications · 2024Article
- Time-series metaproteogenomics of a high-COmicroLife · 2024Article
- CRISPR-influenced symbiosis.Nature microbiology · 2023Article
Corrections and comments
- Commented on by
Authors and funding
26 authors at 11 institutions in 7 countries.
Funding
Abstract
CRISPR-Cas systems defend prokaryotic cells from invasive DNA of viruses, plasmids and other mobile genetic elements. Here, we show using metagenomics, metatranscriptomics and single-cell genomics that CRISPR systems of widespread, uncultivated archaea can also target chromosomal DNA of archaeal episymbionts of the DPANN superphylum. Using meta-omics datasets from Crystal Geyser and Horonobe Underground Research Laboratory, we find that CRISPR spacers of the hosts Candidatus Altiarchaeum crystalense and Ca. A. horonobense, respectively, match putative essential genes in their episymbionts' genomes of the genus Ca. Huberiarchaeum and that some of these spacers are expressed in situ. Metabolic interaction modelling also reveals complementation between host-episymbiont systems, on the basis of which we propose that episymbionts are either parasitic or mutualistic depending on the genotype of the host. By expanding our analysis to 7,012 archaeal genomes, we suggest that CRISPR-Cas targeting of genomes associated with symbiotic archaea evolved independently in various archaeal lineages.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.