Evidence map›Paper›PMID 37500800›Full record

ArticlePediatric surgery international2023

Concurrent application of interferon-gamma and vincristine inhibits tumor growth in an orthotopic neuroblastoma mouse model.

Jasmine Zeki, Burcin Yavuz, Lauren Wood, Hiroyuki Shimada, David L Kaplan, Bill Chiu

Abstract read
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In one paragraph

Article in Pediatric surgery international, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Jasmine ZekiDepartment of Surgery, Stanford University, 453 Quarry Road, Palo Alto, CA, 94304, USA.
Burcin YavuzDepartment of Biomedical Engineering, Tufts University, 4 Colby Street, Medford, MA, 02155, USA.
Lauren WoodDepartment of Surgery, Stanford University, 453 Quarry Road, Palo Alto, CA, 94304, USA.
Hiroyuki ShimadaDepartment of Pathology, Stanford University, Stanford, CA, USA.
David L KaplanDepartment of Biomedical Engineering, Tufts University, 4 Colby Street, Medford, MA, 02155, USA. david.kaplan@tufts.edu.
Bill ChiuDepartment of Surgery, Stanford University, 453 Quarry Road, Palo Alto, CA, 94304, USA. bhsc@stanford.edu.
Stanford University · USTufts University · US

Funding

Focal Sustained Release Chemotherapy-Loaded Biomaterials at Tumor SitesR01NS094218 · NINDS · TUFTS UNIVERSITY MEDFORD · PI CHIU, BILL, KAPLAN, DAVID L. · 2017 to 2021
$1.7M
NIH HHS R01NS094218
6 · The paper itself

Abstract

purposeTumor-associated macrophages are present within neuroblastoma, and interferon-gamma (IFN-γ) can polarize macrophages into cancer-inhibiting M1 type. We hypothesize that treating neuroblastoma with interferon-gamma (IFN-γ) can suppress tumor growth, and the concurrent treatment with IFN-γ and vincristine can lead to enhanced tumor killing as compared to vincristine alone.

methodsWe loaded IFN-γ or vincristine into silk biomaterials and recorded the amount released over time. Orthotopic, syngeneic neuroblastoma xenografts were generated by injecting 9464D cells into adrenal gland of C57BL/6 mice, and IFN-γ-loaded and/or vincristine-loaded silk biomaterials were implanted into the tumor once the tumors reached 100 mm

results1-2% of IFN-γ and 70% of vincristine were released from the biomaterials by the fifth day. Combining IFN-γ and vincristine significantly slowed tumor growth as compared to the controls (12.2 ± 2.7 days to reach 800 mm

conclusionLocal delivery of sustained release IFN-γ can inhibit neuroblastoma tumor growth by itself and in combination with vincristine.

Indexed as

Interferon-gammaNeuroblastomaVincristineAnimalsBiocompatible MaterialsDisease Models, AnimalHumansMiceMice, Inbred C57BLSilkBiocompatible MaterialsInterferon-gammaSilkVincristineImmunotherapyInterferon-gammaNeuroblastomaOrthotopic mouse modelSustained delivery

Identifiers

PMID37500800
OpenAlexW4385324585

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.