ArticleCell research2023
Maternal aging increases offspring adult body size via transmission of donut-shaped mitochondria.
Article in Cell research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 16 citations in OpenAlex.
- Developmental priming of adult proteostasis and longevity by NuA4 complex activity in early life.The EMBO journal · 2026Article
- 630 nm LED phototherapy enhances ovarian function and fertility potential in advanced reproductive age females.Bioengineering & translational medicine · 2026Article
- Association between parental age at childbirth and timing of puberty in children: an 8-year cohort study.Biology of sex differences · 2026Article
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- Chemical synchronization using household bleach can affect development, behavior and lifespan inAnimal cells and systems · 2026Article
- Effects of Combined Exercise Training on Modulating Fine Particulate Matter-Induced Skeletal Muscle Damage in Offspring Gestationally Exposed.Journal of cachexia, sarcopenia and muscle · 2025Article
- Ciliary IFT-B Transportation Plays an Important Role in Human Endometrial Receptivity Establishment and is Disrupted in Recurrent Implantation Failure Patients.Cell proliferation · 2025Article
- Pharmacological targeting of the mitochondrial phosphatase PTPMT1 sensitizes hepatocellular carcinoma to ferroptosis.Cell death & disease · 2025Article
- Redox regulation: mechanisms, biology and therapeutic targets in diseases.Signal transduction and targeted therapy · 2025Review
- Article
- Development and Application of Cationic Nile Blue Probes in Live-Cell Super-Resolution Imaging and Specific Targeting to Mitochondria.ACS central science · 2024Article
- Maternal age effects on offspring lifespan and reproduction vary within a species.Ecology and evolution · 2024Article
- Impact of photobleaching on quantitative, spatio-temporal, super-resolution imaging of mitochondria in liveNpj imaging · 2024Article
Corrections and comments
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Authors and funding
16 authors at 3 institutions in 2 countries.
Funding
Abstract
Maternal age at childbearing has continued to increase in recent decades. However, whether and how it influences offspring adult traits are largely unknown. Here, using adult body size as the primary readout, we reveal that maternal rather than paternal age has an evolutionarily conserved effect on offspring adult traits in humans, Drosophila, and Caenorhabditis elegans. Elucidating the mechanisms of such effects in humans and other long-lived animals remains challenging due to their long life course and difficulties in conducting in vivo studies. We thus employ the short-lived and genetically tractable nematode C. elegans to explore the mechanisms underlying the regulation of offspring adult trait by maternal aging. By microscopic analysis, we find that old worms transmit aged mitochondria with a donut-like shape to offspring. These mitochondria are rejuvenated in the offspring's early life, with their morphology fully restored before adulthood in an AMPK-dependent manner. Mechanistically, we demonstrate that early-life mitochondrial dysfunction activates AMPK, which in turn not only alleviates mitochondrial abnormalities but also activates TGFβ signaling to increase offspring adult size. Together, our findings provide mechanistic insight into the ancient role of maternal aging in shaping the traits of adult offspring.
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