Evidence map›Paper›PMID 37500653›Full record

ArticleNature communications2023

Rapid prototyping of high-resolution large format microfluidic device through maskless image guided in-situ photopolymerization.

Ratul Paul, Yuwen Zhao, Declan Coster, Xiaochen Qin, Khayrul Islam, Yue Wu, Yaling Liu

Abstract read
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Biomicrofluidics · 2024
    Article
  7. Article
  8. Article
  9. Acoustofluidic Engineering of Functional Vessel-on-a-Chip.ACS biomaterials science & engineering · 2023
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ratul PaulDepartment of Mechanical Engineering and Mechanics, Lehigh University, Bethlehem, PA, 18015, USA.ORCID http://orcid.org/0000-0003-0188-4365
Yuwen ZhaoDepartment of Bioengineering, Lehigh University, Bethlehem, PA, 18015, USA.
Declan CosterDepartment of Electrical and Computer Engineering, Lehigh University, Bethlehem, PA, 18015, USA.
Xiaochen QinDepartment of Bioengineering, Lehigh University, Bethlehem, PA, 18015, USA.ORCID http://orcid.org/0000-0003-0051-2500
Khayrul IslamDepartment of Mechanical Engineering and Mechanics, Lehigh University, Bethlehem, PA, 18015, USA.
Yue WuDepartment of Bioengineering, Lehigh University, Bethlehem, PA, 18015, USA.ORCID http://orcid.org/0000-0002-6564-2093
Yaling LiuDepartment of Mechanical Engineering and Mechanics, Lehigh University, Bethlehem, PA, 18015, USA. yal310@lehigh.edu.ORCID http://orcid.org/0000-0002-4519-3358

Funding

An Affordable and Versatile Two-Dimensional Cell Isolation and Tracking Platform Based on Image Machine Learning and Maskless Photolithography Single Cell EncapsulationR21EB033102 · NIBIB · LEHIGH UNIVERSITY · PI BERDICHEVSKY, YEVGENY · 2022 to 2023
$434k
NIBIB NIH HHS R21 EB033102
6 · The paper itself

Abstract

Microfluidic devices have found extensive applications in mechanical, biomedical, chemical, and materials research. However, the high initial cost, low resolution, inferior feature fidelity, poor repeatability, rough surface finish, and long turn-around time of traditional prototyping methods limit their wider adoption. In this study, a strategic approach to a deterministic fabrication process based on in-situ image analysis and intermittent flow control called image-guided in-situ maskless lithography (IGIs-ML), has been proposed to overcome these challenges. By using dynamic image analysis and integrated flow control, IGIs-ML provides superior repeatability and fidelity of densely packed features across a large area and multiple devices. This general and robust approach enables the fabrication of a wide variety of microfluidic devices and resolves critical proximity effect and size limitations in rapid prototyping. The affordability and reliability of IGIs-ML make it a powerful tool for exploring the design space beyond the capabilities of traditional rapid prototyping.

Identifiers

PMID37500653
PMCPMC10374892

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.