ArticleNature communications2023
Increasing number of long-lived ancestors marks a decade of healthspan extension and healthier metabolomics profiles.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- Exceptional Parental Longevity and Onset of Morbidity and Mortality Across Cohorts.JAMA network open · 2026Article
- Developmental origins of exceptional health and survival: a four-generation family cohort study.Nature communications · 2026Article
- Low genetic risk for coronary artery disease underlies multigenerational longevity and healthy aging.GeroScience · 2026Article
- Familial healthy aging and longevity: the role of spouses.BMC medicine · 2026Article
- Reproduction history and health-promoting behaviors are associated with successful aging and survival.GeroScience · 2026Article
- Rare longevity-associated variants, including a reduced-function mutation in cGAS, identified in multigenerational long-lived families.bioRxiv : the preprint server for biology · 2025Article
- Protein Catabolites as Blood-Based Biomarkers of Aging Physiology: Findings From the Dog Aging Project.Aging cell · 2025Article
- Disease accumulation and distribution across the lifespan in Swedish centenarians and non-centenarians: a nationwide life course comparison of longevity and health resilience.EClinicalMedicine · 2025Article
- Penalized Reduced Rank Regression for Multi-Outcome Survival Data Supports a Common Metabolic Risk Score for Age-Related Diseases.Statistics in medicine · 2025Article
- Anti-senescence therapies: a new concept to address cardiovascular disease.Cardiovascular research · 2025Review
- Determinants and inequities in healthy working life expectancy in China.Nature medicine · 2024Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Globally, the lifespan of populations increases but the healthspan is lagging behind. Previous research showed that survival into extreme ages (longevity) clusters in families as illustrated by the increasing lifespan of study participants with each additional long-lived family member. Here we investigate whether the healthspan in such families follows a similar quantitative pattern using three-generational data from two databases, LLS (Netherlands), and SEDD (Sweden). We study healthspan in 2143 families containing index persons with 26 follow-up years and two ancestral generations, comprising 17,539 persons. Our results provide strong evidence that an increasing number of long-lived ancestors associates with up to a decade of healthspan extension. Further evidence indicates that members of long-lived families have a delayed onset of medication use, multimorbidity and, in mid-life, healthier metabolomic profiles than their partners. We conclude that both lifespan and healthspan are quantitatively linked to ancestral longevity, making family data invaluable to identify protective mechanisms of multimorbidity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.