Evidence map›Paper›PMID 37500479›Full record

ArticleJournal of neurointerventional surgery2024

Novel endovascular transmural technique for pharmacological block of superior cervical ganglion prevents sympathetic-mediated cerebral vasospasm.

Wi Jin Kim, Hasitha Milan Samarage, Matiar Jafari, David Zarrin, Keshav Goel, Xin Qi, Anthony C Wang, Jeremiah Johnson, Geoffrey P Colby

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurointerventional surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Wi Jin KimDepartment of Neurosurgery, University of California Los Angeles, Los Angeles, California, USA.ORCID http://orcid.org/0000-0002-0073-5408
Hasitha Milan SamarageDepartment of Neurosurgery, University of California Los Angeles, Los Angeles, California, USA.
Matiar JafariDepartment of Neurosurgery, University of California Los Angeles, Los Angeles, California, USA.
David ZarrinDavid Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA.ORCID http://orcid.org/0000-0001-8666-4972
Keshav GoelUniversity of California Los Angeles, Los Angeles, California, USA.
Xin QiSchool of Medicine, UCLA, Los Angeles, California, USA.
Anthony C WangDepartment of Neurosurgery, University of California Los Angeles, Los Angeles, California, USA.
Jeremiah JohnsonDepartment of Neurosurgery, University of California Los Angeles, Los Angeles, California, USA.
Geoffrey P ColbyDepartment of Neurosurgery, University of California Los Angeles, Los Angeles, California, USA gcolby@mednet.ucla.edu.
University of California, Los Angeles · US

Funding

UCLA Neurosurgery Research Training and Education ProgramR25NS079198 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LIAU, LINDA M · 2012 to 2021
$1.2M
NINDS NIH HHS R25 NS079198
6 · The paper itself

Abstract

backgroundSympathetic-mediated vasoconstriction from the superior cervical ganglion (SCG) is a significant contributor to cerebral vasospasm. Inhibition of the SCG has been shown to improve cerebral blood flow and reverse cerebral vasospasm in swine models. We evaluated the efficacy of a novel minimally invasive endovascular approach to target and pharmacologically inhibit the SCG, using a Micro-Infusion Device for transmural drug delivery.

methodsEight SCGs in four Yorkshire swine were surgically identified. After confirming appropriate sympathetic-mediated intracranial vasoconstriction response with SCG stimulation, an endovascular Micro-Infusion Device was used for transmural targeting of the SCG and delivery of 1.5-2 mL of 1% lidocaine-contrast mixture to the perivascular space. Digital subtraction angiography was obtained at: (1) baseline; (2) with SCG stimulation; and (3) after lidocaine delivery to the SCG using the Micro-Infusion Device with concurrent SCG stimulation. Vessel diameters were measured and compared.

resultsEndovascular transmural delivery of lidocaine to the SCG and carotid perivascular tissue using the Micro-Infusion Device successfully inhibited sympathetic-mediated vasoconstriction response. Measured vessel diameters after lidocaine delivery were comparable to baseline despite SCG stimulation.

conclusionA novel endovascular technique of transmural delivery of lidocaine to the SCG and carotid artery perivascular tissues successfully inhibits the sympathetic input to the cerebral vasculature and modulates sympathetic-mediated cerebral vasospasm. These results suggest promising steps towards translation to potential clinical use for patients suffering from cerebral vasospasm.

Indexed as

Endovascular ProceduresLidocaineSuperior Cervical GanglionVasospasm, IntracranialAnesthetics, LocalAnimalsSwineAnesthetics, LocalLidocaineangiographyblood flowinterventionnecktechnique

Identifiers

PMID37500479
PMCPMC10818000
OpenAlexW4385329371

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.