Evidence map›Paper›PMID 37500421›Full record

ReviewTrends in endocrinology and metabolism: TEM2023

New perspectives on sex differences in learning and memory.

Aaron W Fleischer, Karyn M Frick

Abstract readReview
In one paragraph

Review in Trends in endocrinology and metabolism: TEM, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Combinatorial targeting of NMDARs and 5-HTAlzheimer's research & therapy · 2025
    Article
  10. Review
  11. Review
  12. Article
  13. Review
  14. Review
  15. Article
  16. Brain health: A concern for anaesthesiologists and intensivists.European journal of anaesthesiology and intensive care · 2024
    Review
  17. Article
  18. Article
  19. Sex differences in the context dependency of episodic memory.Frontiers in behavioral neuroscience · 2024
    Article
  20. PeerJ · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Aaron W FleischerDepartment of Psychology, University of Wisconsin-Milwaukee, Milwaukee, WI 53211, USA. Electronic address: fleisc54@uwm.edu.
Karyn M FrickDepartment of Psychology, University of Wisconsin-Milwaukee, Milwaukee, WI 53211, USA. Electronic address: frickk@uwm.edu.

Funding

Mechanisms underlying memory regulation by 17beta-estradiol, canonical Wnt signaling, and BDNF in male and female miceR01MH107886 · NIMH · UNIVERSITY OF WISCONSIN MILWAUKEE · PI FRICK, KARYN M · 2016 to 2020
$1.9M
Hormone and enrichment effects on memory in aging miceR01AG022525 · NIA · YALE UNIVERSITY · PI FRICK, KARYN M · 2005 to 2009
$1.3M
Development of ER-beta Agonists to Treat Post-Menopausal Memory DeclineR15GM118304 · NIGMS · CONCORDIA UNIVERSITY WISCONSIN · PI SEM, DANIEL S · 2015 to 2018
$820k
Development of EGX358, an ER-beta Agonist to Treat Hot Flashes & Menopause-Related Memory LossR43AG079715 · NIA · ESTRIGENIX THERAPEUTICS, INC. · PI DONALDSON, WILLIAM A · 2022 to 2022
$299k
The role of extracellular matrix in estradiol regulation of hippocampal memory consolidationF32MH118782 · NIMH · UNIVERSITY OF WISCONSIN MILWAUKEE · PI GROSS, KELLIE · 2019 to 2021
$195k
Estrogenic-cholinergic interactions in memory modulationR03MH065460 · NIMH · YALE UNIVERSITY · PI FRICK, KARYN M · 2003 to 2004
$156k
The role of hippocampal astrocytes in memory and estrogenic regulation of memoryF31MH118822 · NIMH · UNIVERSITY OF WISCONSIN MILWAUKEE · PI TAXIER, LISA R · 2019 to 2021
$119k
NIA NIH HHS R01 AG022525NIA NIH HHS R43 AG079715NIGMS NIH HHS R15 GM118304NIMH NIH HHS F31 MH118822NIMH NIH HHS F32 MH118782NIMH NIH HHS R01 MH107886NIMH NIH HHS R03 MH065460
6 · The paper itself

Abstract

Females have historically been disregarded in memory research, including the thousands of studies examining roles for the hippocampus, medial prefrontal cortex, and amygdala in learning and memory. Even when included, females are often judged based on male-centric behavioral and neurobiological standards, generating and perpetuating scientific stereotypes that females exhibit worse memories compared with males in domains such as spatial navigation and fear. Recent research challenges these dogmas by identifying sex-specific strategies in common memory tasks. Here, we discuss rodent data illustrating sex differences in spatial and fear memory, as well as the neural mechanisms underlying memory formation. The influence of sex steroid hormones in both sexes is discussed, as is the importance to basic and translational neuroscience of studying sex differences.

Indexed as

LearningSex CharacteristicsAnimalsFemaleGonadal Steroid HormonesHippocampusMaleGonadal Steroid Hormonesestrogenfear memoryhippocampusmedial prefrontal cortexspatial memory

Identifiers

PMID37500421
PMCPMC10617789

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.