Evidence map›Paper›PMID 37500295›Full record

ArticleTrends in pharmacological sciences2023

Human skin-on-a-chip for mpox pathogenesis studies and preclinical drug evaluation.

Jia Zhu, Hasan E Abaci

Open access · greenAbstract read
In one paragraph

Article in Trends in pharmacological sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Jia ZhuDepartment of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, WA, USA; Vaccine and Infectious Disease Division, Fred Hutch Cancer Center, Seattle, WA, USA; Institute of Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, USA. Electronic address: jiazhu@uw.edu.
Hasan E AbaciDepartment of Dermatology, Columbia University Medical Center, New York, NY, USA.
Columbia University Irving Medical Center · USInfectious Disease Research Institute · US

Funding

Modeling of human HSV infection: development of immune-competent 3D skin-on-chip with vascular perfusionR01AI143773 · NIAID · UNIVERSITY OF WASHINGTON · PI ZHU, JIA · 2020 to 2024
$2.7M
Biofabricated 3-D skin model for antiviral drug discovery against human HSV infectionU18TR003208 · NCATS · UNIVERSITY OF WASHINGTON · PI ZHU, JIA · 2020 to 2021
$1.0M
Synthetic Developmental Tissue Engineering of Human Hair FolliclesK01AR072131 · NIAMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ABACI, HASAN ERBIL · 2017 to 2022
$636k
NCATS NIH HHS U18 TR003208NIAID NIH HHS R01 AI143773NIAMS NIH HHS K01 AR072131
6 · The paper itself

Abstract

Timely intervention of preventative and therapeutic measures abated a 2022 mpox global outbreak. However, the high transmissibility and unique pathological characteristics of mpox demand further investigation. Here, we discuss the potentials of human skin-on-a-chip as a valuable model for mpox disease evaluation, to achieve in-depth physiological understanding and desirable therapeutic predictive capabilities.

Indexed as

Mpox, MonkeypoxDrug Evaluation, PreclinicalHumansLab-On-A-Chip Devicesantiviral therapeuticsbioengineered skinendothelialized vascular networkmpoxskin-on-a-chip

Identifiers

PMID37500295
PMCPMC10811284
OpenAlexW4385274054

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.