ArticleJournal of endodontics2023
Genome-wide Association Study Identifies Novel Risk Loci for Apical Periodontitis.
Article in Journal of endodontics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.
- Pooled it
- Examining Electronic Health Records to Investigate Sex Differences in Oral Diseases and Conditions.Clinical and experimental dental research · 2026Article
- Bibliometric Analysis of the Worldwide Scientific Production on Periapical Lesions in Veterinary Medicine: Visualization, Emerging Patterns, and Thematic Evolution.Veterinary medicine international · 2026Article
- Concordance between male- and female-specific GWAS results helps define underlying genetic architecture of complex traits.Nature communications · 2025Article
- Prevalence of Glutathione-S-Transferase T and M Deletion Polymorphisms in Apical Periodontitis: a Two-Center Observational Study.Acta stomatologica Croatica · 2025Article
- Genome-wide association study of pulpal and apical diseases.Nature communications · 2025Article
- A Principled Framework for Mendelian Randomization in Oral Health Research.Journal of periodontal research · 2025Article
- Review
- Genetic risk factors for periodontitis: a genome-wide association study using UK Biobank data.Clinical oral investigations · 2025Article
- Advances in clinical and translational research in endodontics: A comprehensive overview.Brazilian dental journal · 2025Review
- Bridging the gap between omics research and dental practice.BDJ open · 2024Review
- Assessment of Systemic Condition and Smoking Impact Over Incidence of Apical Periodontitis.Cureus · 2024Article
Corrections and comments
- Update of
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
introductionApical periodontitis (AP) is a common consequence of root canal infection leading to periapical bone resorption. Microbial and host genetic factors and their interactions have been shown to play a role in AP development and progression. Variations in a few genes have been reported in association with AP; however, the lack of genome-wide studies has hindered progress in understanding the molecular mechanisms involved. Here, we report the first genome-wide association study of AP in a large and well-characterized population.
methodsMale and female adults (n = 932) presenting with deep caries and AP (cases), or deep caries without AP (controls) were included. Genotyping was performed using the Illumina Expanded Multi-Ethnic Genotyping Array (MEGA). Single-variant association testing was performed adjusting for sex and 5 principal components. Subphenotype association testing, analyses of genetically regulated gene expression, polygenic risk score, and phenome-wide association (PheWAS) analyses were also conducted.
resultsEight loci reached near genome-wide significant association with AP (P < 5 × 10
conclusionsThis study identified novel genes/loci contributing to AP and specific contributions to AP risk in men and women. Importantly, we identified additional systemic conditions significantly associated with AP risk. Our findings provide strong evidence for host-mediated effects on AP susceptibility.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.