Evidence map›Paper›PMID 37499733›Full record

ArticleBrain research2023

Tight control of the APP-Mint1 interaction in regulating amyloid production.

Shawna M Henry, Sabrina A Kistler, Gavin D Lagani, Christian R O Bartling, Dennis Özcelik, Vita Sereikaite, Kristian Strømgaard, Uwe Beffert, Angela Ho

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Shawna M HenryDepartment of Biology, Boston University, Boston, MA, USA.
Sabrina A KistlerDepartment of Biology, Boston University, Boston, MA, USA.
Gavin D LaganiDepartment of Biology, Boston University, Boston, MA, USA.
Christian R O BartlingDepartment of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark.
Dennis ÖzcelikDepartment of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark.
Vita SereikaiteDepartment of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark.
Kristian StrømgaardDepartment of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark.
Uwe BeffertDepartment of Biology, Boston University, Boston, MA, USA.
Angela HoDepartment of Biology, Boston University, Boston, MA, USA. Electronic address: aho1@bu.edu.
Boston University · USUniversity of Copenhagen · DK

Funding

Mint Adaptor Proteins in APP Binding and ProcessingR01AG044499 · NIA · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI HO, ANGELA · 2014 to 2018
$1.7M
APP mimetic peptide as a potential therapeutic target to reduce amyloid generationR21AG072433 · NIA · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI HO, ANGELA · 2021 to 2021
$454k
NIA NIH HHS R01 AG044499NIA NIH HHS R21 AG072433
6 · The paper itself

Abstract

Generation of amyloid-β (Aβ) peptides through the proteolytic processing of the amyloid precursor protein (APP) is a pathogenic event in Alzheimer's disease (AD). APP is a transmembrane protein and endocytosis of APP mediated by the YENPTY motif is a key step in Aβ generation. Mints, a family of cytosolic adaptor proteins, directly bind to the YENPTY motif of APP and facilitate APP trafficking and processing. Here, we generated and examined two Mint1 mutants, Tyr633Ala of Mint1 (Mint1

Indexed as

Alzheimer DiseaseAmyloid beta-Protein PrecursorAdaptor Proteins, Signal TransducingAmyloid beta-PeptidesAmyloid Precursor Protein SecretasesAnimalsHumansMiceNerve Tissue ProteinsNeuronsAdaptor Proteins, Signal TransducingAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAmyloid Precursor Protein SecretasesApba1 protein, mouseNerve Tissue ProteinsAlzheimer’s diseaseAmyloidAPPMint1

Identifiers

PMID37499733
PMCPMC10529462
OpenAlexW4385235283

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.