Multiscale theoretical model shows that aging-related mechanical degradation of cortical bone is driven by microstructural changes in addition to porosity.

André Gutiérrez Marty, Paul E Barbone, Elise F Morgan

Open access · greenAbstract read

In one paragraph

Article in Journal of the mechanical behavior of biomedical materials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.7field-weighted citation impact, top 33% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

Increased AGE Cross-Linking Reduces the Mechanical Properties of Osteons.JOM (Warrendale, Pa. : 1989) · 2024
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

André Gutiérrez MartyMechanical Engineering, Boston University, 110 Cummington Mall, Boston, 02115, MA, USA; Center for Multiscale and Translational Mechanobiology, Boston University, 110 Cummington Mall, Boston, 02115, MA, USA. Electronic address: gutier@bu.edu.

Paul E BarboneMechanical Engineering, Boston University, 110 Cummington Mall, Boston, 02115, MA, USA; Center for Multiscale and Translational Mechanobiology, Boston University, 110 Cummington Mall, Boston, 02115, MA, USA. Electronic address: barbone@bu.edu.

Elise F MorganMechanical Engineering, Boston University, 110 Cummington Mall, Boston, 02115, MA, USA; Center for Multiscale and Translational Mechanobiology, Boston University, 110 Cummington Mall, Boston, 02115, MA, USA; Biomedical Engineering, Boston University, 44 Cummington Mall, Boston, 02115, MA, USA. Electronic address: efmorgan@bu.edu.

Boston University · US

Funding

3-D Visualization and Prediction of Vertebral FracturesR01AR054620 · NIAMS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI MORGAN, ELISE F · 2008 to 2025

$6.7M

NIAMS NIH HHS R01 AR054620

6 · The paper itself

Abstract

This study aims to gain mechanistic understanding of how aging-related changes in the microstructure of cortical bone drive mechanical consequences at the macroscale. To that end, cortical bone was modeled as a bundle of elastic-plastic, parallel fibers, which represented osteons and interstitial tissue, loaded in uniaxial tension. Distinct material properties were assigned to each fiber in either the osteon or interstitial fiber "families." Models representative of mature (20-60 yrs.) bone, and elderly (60+) bone were created by modeling aging via the following changes to the input parameters: (i) increasing porosity from 5% to 15%, (ii) increasing the ratio of the number of osteon fibers relative to interstitial fibers from 40% to 50%, and (iii) changing the fiber material properties from representing mature bone samples to representing elderly bone samples (i.e., increased strength and decreased toughness of interstitial fibers together with decreased toughness of osteon fibers). To understand the respective contributions of these changes, additional models isolating one or two of each of these were also created. From the computed stress-strain curve for the fiber bundle, the yield point (ϵ

Indexed as

Bone and BonesCortical BoneAgedAgingHaversian SystemHumansModels, TheoreticalPorosityBiomechanicsBone micromechanicsCompact boneConstitutive modelingHaversian boneInelastic behavior

Identifiers

PMID37499524

DOI10.1016/j.jmbbm.2023.106029

PMCPMC10528045

OpenAlexW4384699652

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.