Evidence map›Paper›PMID 37499367›Full record

ArticleBiochemical and biophysical research communications2023

Sex differences in the effects of brown adipocyte CD47 deficiency on age-related weight change and glucose homeostasis.

Dong Li, Taesik Gwag, Shuxia Wang

Open access · greenAbstract read
In one paragraph

Article in Biochemical and biophysical research communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
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  4. Review
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  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Dong LiDepartment of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY, 40536, USA; Lexington VA Medical Center, Lexington, KY, 40502, USA.
Taesik GwagDepartment of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY, 40536, USA; Lexington VA Medical Center, Lexington, KY, 40502, USA.
Shuxia WangDepartment of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY, 40536, USA; Lexington VA Medical Center, Lexington, KY, 40502, USA. Electronic address: swang7@uky.edu.
University of Kentucky · US

Funding

WU P&FP30DK020579 · NIDDK · WASHINGTON UNIVERSITY · PI James Alexander Fitzpatrick · 2013 to 2026
$27.1M
Pilot Projects ProgramP30GM127211 · NIGMS · UNIVERSITY OF KENTUCKY · PI CASSIS, LISA A · 2018 to 2022
$5.7M
Role of SMPDL3B in obesity-associated non-alcoholic fatty liver diseaseR01DK131786 · NIDDK · UNIVERSITY OF KENTUCKY · PI Shuxia Wang · 2022 to 2026
$2.5M
Thrombospondin 1 in obesity associated inflammation and insulin resistanceR01DK098176 · NIDDK · UNIVERSITY OF KENTUCKY · PI WANG, SHUXIA · 2014 to 2017
$1.2M
CD47 as a therapeutic target for obesityI01BX004252 · VA · VA MEDICAL CENTER - LEXINGTON, KY · PI WANG, SHUXIA · 2019 to 2023
–
BLRD VA I01 BX004252NIDDK NIH HHS P30 DK020579NIDDK NIH HHS R01 DK098176NIDDK NIH HHS R01 DK131786NIGMS NIH HHS P30 GM127211
6 · The paper itself

Abstract

Our previous studies demonstrated that mice with global CD47 deficiency are lean and resistant to diet or aging-associated obesity and metabolic complications. This protective effect is partially through modulating brown fat function. To definitively determine the role of brown fat CD47 in age-related metabolic homeostasis, inducible brown adipocyte-specific cd47 deficient mice were generated by crossbreeding cd47 floxed mice with UCP1-Cre

Indexed as

Adipocytes, BrownCD47 AntigenAdipose Tissue, BrownAnimalsDiet, High-FatFemaleGlucoseHomeostasisMaleMiceMice, Inbred C57BLMice, KnockoutSex CharacteristicsThermogenesisCD47 AntigenGlucoseAgeBody weightBrown fatCD47Glucose homeostasisSex-difference

Identifiers

PMID37499367
PMCPMC10810338
OpenAlexW4385076195

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.