ArticleProceedings of the National Academy of Sciences of the United States of America2023
Identification and targeting of a unique Na
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In one paragraph
Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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0cells of the map it votes in
30citing papers in PubMed
6.5field-weighted citation impact, top 3% of its field
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 42 citations in OpenAlex.
- Alternative splicing in voltage-gated sodium channels: mechanisms, regulatory networks and therapeutic implications.Annals of medicine · 2026Review
- Targeting Spinal Dorsal Horn Sensitisation in Chronic Pain: Mechanisms and Translational Strategies.Neuroscience bulletin · 2026Review
- Peripheral NabioRxiv : the preprint server for biology · 2026Article
- Spared but Not Silent: Ion Channel Plasticity in Uninjured Sensory Neurons in Neuropathic Pain.International journal of molecular sciences · 2026Review
- NabioRxiv : the preprint server for biology · 2026Article
- Targeting CRMP2 for Chronic Pain: From Molecular Mechanisms to Therapeutic Strategies.Biomedicines · 2026Review
- Recombinant dimeric PICK1 peptide inhibitors for long-term relief of chronic pain by AAV therapeutics.Cell reports. Medicine · 2026Article
- A comprehensive review on pain: Model, target, therapy, and prospect (Review).International journal of molecular medicine · 2026Review
- Potential Roles of G Protein-Coupled Receptor 30 (GPR30) in Migraine Pathophysiology.Journal of pain research · 2026Review
- Recent advances in the pharmacology of voltage-gated ion channels.Pharmacological reviews · 2025Review
- Article
- Artificial Uterus and Artificial Embryos: Unsolved Tasks.Reproductive sciences (Thousand Oaks, Calif.) · 2025Review
- Targeting sodium channels - challenges for acute pain and the leap to chronic pain.Nature reviews. Neurology · 2025Review
- Enhancing peripheral nerve regeneration with rehabilitation and biomaterial-driven drug delivery strategies.Progress in biomedical engineering (Bristol, England) · 2025Review
- Anti-CV2/CRMP5 autoantibodies as drivers of sensory neuron excitability and pain in rats.Nature communications · 2025Article
- Beyond single targets: leveraging degeneracy in sodium channels for osteoarthritis analgesia.Pain reports · 2025Article
- Sensory neuron-expressed FGF13 controls nociceptive signaling in diabetic neuropathy models.The Journal of clinical investigation · 2025Article
- Spatial transcriptomic profiling of human paravertebral sympathetic chain ganglia reveals diabetes-induced neuroplasticity.bioRxiv : the preprint server for biology · 2025Article
- Voltage-Gated Ion Channels in Neuropathic Pain Signaling.Life (Basel, Switzerland) · 2025Review
- Preclinical Animal Models to Investigate the Role of NaLife (Basel, Switzerland) · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 4 institutions in 1 country.
Kimberly GomezDepartment of Molecular Pathobiology, College of Dentistry, New York University, New York, NY 10010.ORCID 0000-0003-1867-5041
Harrison J StrattonDepartment of Pharmacology, College of Medicine, The University of Arizona, Tucson, AZ 85724.ORCID 0000-0001-7021-853X
Paz DuranDepartment of Molecular Pathobiology, College of Dentistry, New York University, New York, NY 10010.ORCID 0000-0001-8729-8636
Santiago LoyaDepartment of Molecular Pathobiology, College of Dentistry, New York University, New York, NY 10010.
Cheng TangDepartment of Molecular Pathobiology, College of Dentistry, New York University, New York, NY 10010.
Aida Calderon-RiveraDepartment of Molecular Pathobiology, College of Dentistry, New York University, New York, NY 10010.ORCID 0000-0002-0129-2848
Liberty François-MoutalDepartment of Pharmacology, College of Medicine, The University of Arizona, Tucson, AZ 85724.
May KhannaDepartment of Molecular Pathobiology, College of Dentistry, New York University, New York, NY 10010.ORCID 0000-0002-9989-6374
Cynthia L MaduraDepartment of Pharmacology, College of Medicine, The University of Arizona, Tucson, AZ 85724.ORCID 0000-0002-1748-1811
Shizhen LuoDepartment of Pharmacology, College of Medicine, The University of Arizona, Tucson, AZ 85724.ORCID 0000-0001-7654-095X
Bryan McKiverDepartment of Pharmacology and Toxicology and Translational Research Initiative for Pain and Neuropathy, Virginia Commonwealth University, Richmond, VA 23298-0613.ORCID 0000-0002-1447-5803
Edward ChoiDepartment of Pharmacology and Toxicology and Translational Research Initiative for Pain and Neuropathy, Virginia Commonwealth University, Richmond, VA 23298-0613.
Dongzhi RanDepartment of Pharmacology, College of Medicine, The University of Arizona, Tucson, AZ 85724.
Lisa BoinonDepartment of Pharmacology, College of Medicine, The University of Arizona, Tucson, AZ 85724.ORCID 0000-0001-8650-1014
Samantha Perez-MillerDepartment of Molecular Pathobiology, College of Dentistry, New York University, New York, NY 10010.ORCID 0000-0002-9034-3693
M Imad DamajDepartment of Pharmacology and Toxicology and Translational Research Initiative for Pain and Neuropathy, Virginia Commonwealth University, Richmond, VA 23298-0613.
Aubin MoutalDepartment of Pharmacology and Physiology, School of Medicine, St. Louis University, St. Louis, MO 63104.
Rajesh KhannaDepartment of Molecular Pathobiology, College of Dentistry, New York University, New York, NY 10010.ORCID 0000-0002-9066-2969
New York University · USUniversity of Arizona · USVirginia Commonwealth University · USSaint Louis University · US
Funding
CRMP2, mitochondria, and Huntington’s diseaseR01NS098772 · NINDS · INDIANA UNIVERSITY INDIANAPOLIS · PI BRUSTOVETSKY, NICKOLAY, KHANNA, RAJESH · 2017 to 2021
$2.8MSentrin proteases, CRMP2 deSUMOylation, and Chronic PainR01NS120663 · NINDS · UNIVERSITY OF FLORIDA · PI KHANNA, RAJESH · 2020 to 2021
$2.6MExploring CRMP5 as a novel target for Alzheimers diseaseR01NS119263 · NINDS · UNIVERSITY OF ARIZONA · PI Aubin Moutal · 2021 to 2026
$2.2MCRMP2, Nav1.7 sodium channel, and chronic painR01DA042852 · NIDA · UNIVERSITY OF ARIZONA · PI KHANNA, RAJESH · 2017 to 2021
$1.9MVCU Initiative for Maximizing Student Development Program (IMSD)T32GM148403 · NIGMS · VIRGINIA COMMONWEALTH UNIVERSITY · PI AKBARALI, HAMID I, ESCALANTE, CARLOS R · 2023 to 2025
$647kNIDA NIH HHS DA042852NIDA NIH HHS R01 DA042852NIGMS NIH HHS T32 GM148403NINDS NIH HHS NS098772 NS120663NINDS NIH HHS NS119263NINDS NIH HHS R01 NS098772NINDS NIH HHS R01 NS119263NINDS NIH HHS R01 NS120663
Abstract
Small molecules directly targeting the voltage-gated sodium channel (VGSC) Na
Indexed as
Chronic PainNeuralgiaAnimalsGanglia, SpinalHyperalgesiaMacaca mulattaNAV1.7 Voltage-Gated Sodium ChannelNAV1.8 Voltage-Gated Sodium ChannelNAV1.7 Voltage-Gated Sodium ChannelNAV1.8 Voltage-Gated Sodium Channelchronic painCRMP2gene therapyNaV1.7SUMO
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.