ArticlePloS one2023
Genomic characterization and virulence of Streptococcus suis serotype 4 clonal complex 94 recovered from human and swine samples.
Article in PloS one, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed, 7 citations in OpenAlex.
- Innate immune response to Streptococcus suis infection: advances and future challenges.Veterinary research · 2026Review
- Multidrug-resistant and virulent Streptococcus suis strains detected in clinically healthy pigs in Guangdong and Guangxi, China.Veterinary research · 2026Article
- Streptococcus suis in Asia: epidemiology, transmission and zoonotic risk at the animal-human interface.Veterinary research communications · 2026Review
- Non-penicillin -susceptible and linezolid-non-susceptible Streptococcus suis clonal complex 233 from humans.Scientific reports · 2026Article
- Public Awareness and Molecular Characterization ofVeterinary sciences · 2026Article
- Prophage-mediated lysogenic conversion drives virulence evolution and genomic plasticity inMicrobiology spectrum · 2026Article
- Article
- Pathogenic characteristics of an unencapsulated Streptococcus suis serotype 31 strain isolated from a patient in Thailand.Scientific reports · 2025Article
- Genetic diversity and virulence profiling ofJournal of veterinary science · 2025Article
- Genomic characterization and virulence of Streptococcus suis serotype 7 sequence type 373 of clonal complex 94.Veterinary research · 2025Article
- Article
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Authors and funding
12 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Streptococcus suis is a zoonotic pathogen that causes invasive infections in humans and pigs. Herein, we performed genomic analysis of seven S. suis serotype 4 strains belonging to clonal complex (CC) 94 that were recovered from a human patient or from diseased and clinically healthy pigs. Genomic exploration and comparisons, as well as in vitro cytotoxicity tests, indicated that S. suis CC94 serotype 4 strains are potentially virulent. Genomic analysis revealed that all seven strains clustered within minimum core genome group 3 (MCG-3) and had a high number of virulence-associated genes similar to those of virulent serotype 2 strains. Cytotoxicity assays showed that both the human lung adenocarcinoma cell line and HeLa cells rapidly lost viability following incubation for 4 h with the strains at a concentration of 106 bacterial cells. The human serotype 4 strain (ID36054) decreased cell viability profoundly and similarly to the control serotype 2 strain P1/7. In addition, strain ST1689 (ID34572), isolated from a clinically healthy pig, presented similar behaviour in an adenocarcinoma cell line and HeLa cells. The antimicrobial resistance genes tet(O) and ermB that confer resistance to tetracyclines, macrolides, and lincosamides were commonly found in the strains. However, aminoglycoside and streptothricin resistance genes were found only in certain strains in this study. Our results indicate that S. suis CC94 serotype 4 strains are potentially pathogenic and virulent and should be monitored.
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