Evidence map›Paper›PMID 37498548›Full record

ArticleAmerican journal of physiology. Renal physiology2023

Metformin reduces insulin resistance and attenuates progressive renal injury in prepubertal obese Dahl salt-sensitive rats.

Ubong S Ekperikpe, Sautan Mandal, Stephen J Holt, Jacori K Daniels, Tyler D Johnson, Jonita S Cooper, Sarah M Safir, Denise C Cornelius, Jan M Williams

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Renal physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 2 pooled it
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 syntheses or guidelines pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Ubong S EkperikpeDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Mississippi, United States.ORCID 0000-0002-9962-5371
Sautan MandalDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Mississippi, United States.ORCID 0000-0002-4694-2269
Stephen J HoltDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Mississippi, United States.ORCID 0009-0001-8745-9345
Jacori K DanielsDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Mississippi, United States.
Tyler D JohnsonDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Mississippi, United States.
Jonita S CooperDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Mississippi, United States.
Sarah M SafirDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Mississippi, United States.
Denise C CorneliusDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Mississippi, United States.ORCID 0000-0002-6730-6499
Jan M WilliamsDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Mississippi, United States.ORCID 0000-0002-7078-9567
University of Mississippi Medical Center · US

Funding

Training and Mentoring Core P20GM103476 · NIGMS · UNIVERSITY OF SOUTHERN MISSISSIPPI · PI MICHAEL R GARRETT · 2012 to 2026
$60.2M
Role of obesity in preeclamptic pregnancy.P20GM121334 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI Pier Paolo Claudio, Babbette LaMarca · 2017 to 2026
$26.4M
The role of leptin in autoimmune-associated hypertensionP20GM104357 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI HALL, JOHN E · 2013 to 2022
$23.4M
Pilot Projects ProgramP30GM149404 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI John E Hall · 2023 to 2026
$6.3M
Adducin, actin cytoskeleton and cognitive impairmentsR01AG057842 · NIA · UNIVERSITY OF MISSISSIPPI MED CTR · PI WILLIAMS, JAN MICHAEL · 2019 to 2023
$1.9M
Hypertension, Inflammation, and Vascular FunctionR01HL151407 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI CORNELIUS, DENISE CRESHUN · 2020 to 2024
$1.9M
Mechanisms involved in the early development of renal disease associated with prepubertal obesityR01DK109133 · NIDDK · UNIVERSITY OF MISSISSIPPI MED CTR · PI WILLIAMS, JAN MICHAEL · 2017 to 2021
$1.7M
Validation of the Regulatory Potential of Tailed MirtronsR15GM120716 · NIGMS · UNIVERSITY OF SOUTHERN MISSISSIPPI · PI FLYNT, ALEX · 2016 to 2016
$437k
NHLBI NIH HHS R01 HL151407NIA NIH HHS R01 AG057842NIDDK NIH HHS R01 DK109133NIGMS NIH HHS P20 GM103476NIGMS NIH HHS P20 GM104357NIGMS NIH HHS P20 GM121334NIGMS NIH HHS P30 GM149404NIGMS NIH HHS R15 GM120716
6 · The paper itself

Abstract

Prepubertal obesity is currently an epidemic and is considered as a major risk factor for renal injury. Previous studies have demonstrated that insulin resistance contributes to renal injury in obesity, independent of diabetes. However, studies examining the relationship between insulin resistance and renal injury in obese children are lacking. Recently, we reported that progressive renal injury in Dahl salt-sensitive (SS) leptin receptor mutant (SS

Indexed as

HypertensionInsulin ResistanceMetforminPediatric ObesityAnimalsBlood PressureKidneyProteinuriaRatsRats, Inbred DahlSodium Chloride, DietaryMetforminSodium Chloride, Dietaryinsulin resistanceprepubertal obesityproteinuriarenal diseaserenal inflammation

Identifiers

PMID37498548
PMCPMC10639024
OpenAlexW4385295801

What OpenQuestion holds

Texttitle and abstract
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.