Evidence map›Paper›PMID 37498459›Full record

ArticleNeurocritical care2024

Outcomes After Decompressive Surgery for Severe Cerebral Venous Sinus Thrombosis Associated or Not Associated with Vaccine-Induced Immune Thrombosis with Thrombocytopenia: A Multicenter Cohort Study.

Johann Otto Pelz, Martin Kenda, Angelika Alonso, Nima Etminan, Matthias Wittstock, Wolf-Dirk Niesen, Johann Lambeck, Erdem Güresir, Johannes Wach, Tim Lampmann and 15 more

Erratum issuedOpen access · hybridAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurocritical care, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

25 authors at 12 institutions in 2 countries.

Johann Otto PelzDepartment of Neurology, University Hospital Leipzig, Liebigstrasse 20, 04103, Leipzig, Germany. johann.pelz@medizin.uni-leipzig.de.ORCID 0000-0003-4391-2280
Martin KendaDepartment of Neurology and Experimental Neurology, Charité-Universitätsmedizin Berlin, Campus, Virchow-Klinikum, Berlin, Germany.
Angelika AlonsoDepartment of Neurology, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Nima EtminanDepartment of Neurosurgery, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Matthias WittstockDepartment of Neurology, University Medicine Rostock, Rostock, Germany.
Wolf-Dirk NiesenDepartment of Neurology and Clinical Neurophysiology, University Medical Center Freiburg, University of Freiburg, Freiburg, Germany.
Johann LambeckDepartment of Neurology and Clinical Neurophysiology, University Medical Center Freiburg, University of Freiburg, Freiburg, Germany.
Erdem GüresirDepartment of Neurosurgery, University Hospital Bonn, Bonn, Germany.
Johannes WachDepartment of Neurosurgery, University Hospital Bonn, Bonn, Germany.
Tim LampmannDepartment of Neurosurgery, University Hospital Bonn, Bonn, Germany.
Rainer DziewasDepartment of Neurology and Neurorehabilitation, Klinikum Osnabrueck, Osnabrueck, Germany.
Markus WiedmannDepartment of Neurosurgery, Oslo University Hospital, Oslo, Norway.
Hauke SchneiderDepartment of Neurology, University Hospital Augsburg, Augsburg, Germany.
Antonios BayasDepartment of Neurology, University Hospital Augsburg, Augsburg, Germany.
Monika ChristDepartment of Neurology, University Hospital Augsburg, Augsburg, Germany.
Annerose MengelDepartment of Neurology and Stroke, University Hospital Tuebingen, Eberhard-Karls University, Tuebingen, Germany.
Sven PoliDepartment of Neurology and Stroke, University Hospital Tuebingen, Eberhard-Karls University, Tuebingen, Germany.
Dirk BrämerDepartment of Neurology, Jena University Hospital, Jena, Germany.
Dirk LindnerDepartment of Neurosurgery, University Hospital Leipzig, Leipzig, Germany.
Christian PfrepperDivision of Haemostaseology, Medical Department I, University Hospital Leipzig, Leipzig, Germany.
Christian RothDepartment of Neurology, Klinikum Kassel, Kassel, Germany.
Farid Salih *Department of Neurology and Experimental Neurology, Charité-Universitätsmedizin Berlin, Campus, Virchow-Klinikum, Berlin, Germany.
Albrecht Günther *Department of Neurology, Jena University Hospital, Jena, Germany.
Dominik Michalski *Department of Neurology, University Hospital Leipzig, Liebigstrasse 20, 04103, Leipzig, Germany.
IGNITE Study Group
University Hospital Leipzig · DEUniversity Hospital Augsburg · DEUniversity Hospital Bonn · DECharité - Universitätsmedizin Berlin · DEHeidelberg University · DEJena University Hospital · DEUniversity of Freiburg · DEUniversity of Tübingen · DEKlinikum Kassel · DEKlinikum Osnabrück · DEOslo University Hospital · NOUniversity of Rostock · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundClinical observations indicated that vaccine-induced immune thrombosis with thrombocytopenia (VITT)-associated cerebral venous sinus thrombosis (CVST) often has a space-occupying effect and thus necessitates decompressive surgery (DS). While comparing with non-VITT CVST, this study explored whether VITT-associated CVST exhibits a more fulminant clinical course, different perioperative and intensive care unit management, and worse long-term outcome.

methodsThis multicenter, retrospective cohort study collected patient data from 12 tertiary centers to address priorly formulated hypotheses concerning the clinical course, the perioperative management with related complications, extracerebral complications, and the functional outcome (modified Rankin Scale) in patients with VITT-associated and non-VITT CVST, both with DS.

resultsBoth groups, each with 16 patients, were balanced regarding demographics, kind of clinical symptoms, and radiological findings at hospital admission. Severity of neurological symptoms, assessed with the National Institute of Health Stroke Scale, was similar between groups at admission and before surgery, whereas more patients with VITT-associated CVST showed a relevant midline shift (≥ 4 mm) before surgery (100% vs. 68.8%, p = 0.043). Patients with VITT-associated CVST tended to undergo DS early, i.e., ≤ 24 h after hospital admission (p = 0.077). Patients with VITT-associated CVST more frequently received platelet transfusion, tranexamic acid, and fibrinogen perioperatively. The postoperative management was comparable, and complications were evenly distributed. More patients with VITT-associated CVST achieved a favorable outcome (modified Rankin Scale ≤ 3) at 3 months (p = 0.043).

conclusionsAlthough the prediction of individual courses remains challenging, DS should be considered early in VITT-associated CVST because an overall favorable outcome appears achievable in these patients.

Indexed as

Sinus Thrombosis, IntracranialThrombocytopeniaThrombosisDisease ProgressionHumansRetrospective StudiesCerebral venous sinus thrombosisCOVID-19Decompressive surgerySpace-occupying infarctionVaccinationVaccine-induced immune thrombosis with thrombocytopeniaVITT

Identifiers

PMID37498459
PMCPMC10959787
OpenAlexW4385295862

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.