Evidence map›Paper›PMID 37498052›Full record

ReviewGut microbes

Unveiling and harnessing the human gut microbiome in the rising burden of non-communicable diseases during urbanization.

Ziyu Huang, Yue Li, Heekuk Park, Martin Ho, Kanchan Bhardwaj, Naoki Sugimura, Hye Won Lee, Huicui Meng, Matthias P Ebert, Kang Chao and 6 more

Abstract readReview
In one paragraph

Review in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Human microbiome acquisition and transmission.Nature reviews. Microbiology · 2025
    Review
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Ziyu HuangKey Laboratory of Human Microbiome and Chronic Diseases, Sun Yat-Sen University, Ministry of Education, Guangzhou, China.
Yue LiKey Laboratory of Human Microbiome and Chronic Diseases, Sun Yat-Sen University, Ministry of Education, Guangzhou, China.
Heekuk ParkDepartment of Medicine, Division of Infectious Diseases, Columbia University Irving Medical Centre, New York, NY, USA.
Martin HoDepartment of Engineering, University of Cambridge, Cambridge, UK.
Kanchan BhardwajDepartment of Biotechnology, Faculty of Engineering and Technology, Manav Rachna International Institute of Research and Studies, Haryana, India.
Naoki SugimuraGastrointestinal Centre and Institute of Minimally-Invasive Endoscopic Care (iMEC), Sano Hospital, Kobe, Japan.
Hye Won LeeInstitute of Gastroenterology and Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
Huicui MengSchool of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-Sen University, Sun Yat-Sen University, Shenzhen, China.
Matthias P EbertDepartment of Medicine II, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Kang ChaoThe Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
Elke BurgermeisterDepartment of Medicine II, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Aadra P BhattDepartment of Medicine, Centre for Gastrointestinal Biology and Disease, and the Lineberger Comprehensive Cancer Centre, University of North Carolina, Chapel Hill, NC, USA.
Sudarshan A ShettyDepartment of Medical Microbiology and Infection Prevention, University Medical Centre Groningen, Groningen, The Netherlands.
Kai LiKey Laboratory of Human Microbiome and Chronic Diseases, Sun Yat-Sen University, Ministry of Education, Guangzhou, China.
Weiping WenKey Laboratory of Human Microbiome and Chronic Diseases, Sun Yat-Sen University, Ministry of Education, Guangzhou, China.
Tao ZuoKey Laboratory of Human Microbiome and Chronic Diseases, Sun Yat-Sen University, Ministry of Education, Guangzhou, China.ORCID 0000-0001-8450-5281

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The world is witnessing a global increase in the urban population, particularly in developing Asian and African countries. Concomitantly, the global burden of non-communicable diseases (NCDs) is rising, markedly associated with the changing landscape of lifestyle and environment during urbanization. Accumulating studies have revealed the role of the gut microbiome in regulating the immune and metabolic homeostasis of the host, which potentially bridges external factors to the host (patho-)physiology. In this review, we discuss the rising incidences of NCDs during urbanization and their links to the compositional and functional dysbiosis of the gut microbiome. In particular, we elucidate the effects of urbanization-associated factors (hygiene/pollution, urbanized diet, lifestyles, the use of antibiotics, and early life exposure) on the gut microbiome underlying the pathogenesis of NCDs. We also discuss the potential and feasibility of microbiome-inspired and microbiome-targeted approaches as novel avenues to counteract NCDs, including fecal microbiota transplantation, diet modulation, probiotics, postbiotics, synbiotics, celobiotics, and precision antibiotics.

Indexed as

Gastrointestinal MicrobiomeMicrobiotaNoncommunicable DiseasesProbioticsAnti-Bacterial AgentsDysbiosisFecal Microbiota TransplantationHumansPrebioticsUrbanizationAnti-Bacterial AgentsPrebioticsdietfecal microbiota transplantationnon-communicable diseasesthe gut microbiomeurbanization

Identifiers

PMID37498052
PMCPMC10376922

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.