Evidence map›Paper›PMID 37497672›Full record

ArticleStroke2023

Global, Regional, and National Economic Consequences of Stroke.

Jakob V E Gerstl, Sarah E Blitz, Qing Rui Qu, Alexander G Yearley, Philipp Lassarén, Rebecca Lindberg, Saksham Gupta, Ari D Kappel, Juan C Vicenty-Padilla, Edoardo Gaude and 9 more

Registry-linked trialAbstract read
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In one paragraph

Article in Stroke, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06721338 (Safety and Efficacy of Mechanical Thrombectomy Utilizing Reversal Flow), which is not on this map. Cited by 83 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06721338 phase1terminatednot on this mapstarted 2025, after this paper: background citation

Safety and Efficacy of Mechanical Thrombectomy Utilizing Reversal Flow

TypeinterventionalSponsorMediSys Health NetworkRan2025 to 2025Enrolled3ConditionsStroke, Large Vessel OcclusionArmsMechanical thrombectomy via blood flow reversal using BOBBY balloon guide catheter
3 · Its place in the literature

Who cites it

83 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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  7. Achieved home systolic blood pressure and cardiovascular risk in older hypertensive patients.Hypertension research : official journal of the Japanese Society of Hypertension · 2026
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23 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Jakob V E Gerstl *Department of Neurosurgery, Brigham and Women's Hospital (J.V.E.G., S.E.B., A.G.Y., P.L., R.L., S.G., A.D.K., N.J.P., M.A.A.-S., R.D., T.R.S., J.D.B.), Harvard Medical School, MA.ORCID 0000-0002-8100-0517
Sarah E Blitz *Department of Neurosurgery, Brigham and Women's Hospital (J.V.E.G., S.E.B., A.G.Y., P.L., R.L., S.G., A.D.K., N.J.P., M.A.A.-S., R.D., T.R.S., J.D.B.), Harvard Medical School, MA.ORCID 0000-0001-9129-9447
Qing Rui QuDavid H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge (Q.R.Q., J.D.B.).ORCID 0009-0008-4938-5745
Alexander G YearleyDepartment of Neurosurgery, Brigham and Women's Hospital (J.V.E.G., S.E.B., A.G.Y., P.L., R.L., S.G., A.D.K., N.J.P., M.A.A.-S., R.D., T.R.S., J.D.B.), Harvard Medical School, MA.ORCID 0000-0001-9592-8263
Philipp LassarénDepartment of Neurosurgery, Brigham and Women's Hospital (J.V.E.G., S.E.B., A.G.Y., P.L., R.L., S.G., A.D.K., N.J.P., M.A.A.-S., R.D., T.R.S., J.D.B.), Harvard Medical School, MA.ORCID 0000-0003-0833-1093
Rebecca LindbergDepartment of Neurosurgery, Brigham and Women's Hospital (J.V.E.G., S.E.B., A.G.Y., P.L., R.L., S.G., A.D.K., N.J.P., M.A.A.-S., R.D., T.R.S., J.D.B.), Harvard Medical School, MA.
Saksham GuptaDepartment of Neurosurgery, Brigham and Women's Hospital (J.V.E.G., S.E.B., A.G.Y., P.L., R.L., S.G., A.D.K., N.J.P., M.A.A.-S., R.D., T.R.S., J.D.B.), Harvard Medical School, MA.
Ari D KappelDepartment of Neurosurgery, Brigham and Women's Hospital (J.V.E.G., S.E.B., A.G.Y., P.L., R.L., S.G., A.D.K., N.J.P., M.A.A.-S., R.D., T.R.S., J.D.B.), Harvard Medical School, MA.ORCID 0000-0002-6179-8461
Juan C Vicenty-PadillaDepartment of Neurosurgery, San Jorge Children & Women's Hospital, Santurce, PR (J.C.V.-P.).ORCID 0000-0002-1903-8485
Edoardo GaudePockit Diagnostics Ltd., Cambridge, United Kingdom (E.G.).ORCID 0000-0001-8523-7792
Kunakorn C AtchaneeyasakulMission Thrombectomy - Global Access for Stroke Treatment (K.C.A.).ORCID 0000-0003-4695-8962
Shashvat M DesaiHonorHealth Research and Innovation Institute, AZ (S.M.D.).ORCID 0000-0001-9013-6929
Dileep R YavagalDepartment of Neurology, University of Miami & Jackson Memorial Hospitals, FL (D.R.Y.).ORCID 0000-0003-4739-0133
Luca Peruzzotti-JamettiDepartment of Clinical Neurosciences and NIHR Biomedical Research Centre, University of Cambridge, United Kingdom (L.P.-J.).ORCID 0000-0002-9396-5607
Nirav J PatelDepartment of Neurosurgery, Brigham and Women's Hospital (J.V.E.G., S.E.B., A.G.Y., P.L., R.L., S.G., A.D.K., N.J.P., M.A.A.-S., R.D., T.R.S., J.D.B.), Harvard Medical School, MA.ORCID 0000-0003-1725-3293
Mohammed A Aziz-SultanDepartment of Neurosurgery, Brigham and Women's Hospital (J.V.E.G., S.E.B., A.G.Y., P.L., R.L., S.G., A.D.K., N.J.P., M.A.A.-S., R.D., T.R.S., J.D.B.), Harvard Medical School, MA.
Rose DuDepartment of Neurosurgery, Brigham and Women's Hospital (J.V.E.G., S.E.B., A.G.Y., P.L., R.L., S.G., A.D.K., N.J.P., M.A.A.-S., R.D., T.R.S., J.D.B.), Harvard Medical School, MA.ORCID 0000-0003-2641-6496
Timothy R SmithDepartment of Neurosurgery, Brigham and Women's Hospital (J.V.E.G., S.E.B., A.G.Y., P.L., R.L., S.G., A.D.K., N.J.P., M.A.A.-S., R.D., T.R.S., J.D.B.), Harvard Medical School, MA.ORCID 0009-0003-0691-7530
Joshua D BernstockDepartment of Neurosurgery, Brigham and Women's Hospital (J.V.E.G., S.E.B., A.G.Y., P.L., R.L., S.G., A.D.K., N.J.P., M.A.A.-S., R.D., T.R.S., J.D.B.), Harvard Medical School, MA.ORCID 0000-0002-7814-3867

Funding

Wellcome Trust G105713
6 · The paper itself

Abstract

backgroundAn understanding of global, regional, and national macroeconomic losses caused by stroke is important for allocation of clinical and research resources. The authors investigated the macroeconomic consequences of stroke disease burden in the year 2019 in 173 countries.

methodsDisability-adjusted life year data for overall stroke and its subtypes (ischemic stroke, intracerebral hemorrhage, and subarachnoid hemorrhage) were collected from the GBD study (Global Burden of Disease) 2019 database. Gross domestic product (GDP, adjusted for purchasing power parity [PPP]) data were collected from the World Bank; GDP and disability-adjusted life year data were combined to estimate macroeconomic losses using a value of lost welfare (VLW) approach. All results are presented in 2017 international US dollars adjusted for PPP.

resultsGlobally, in 2019, VLW due to stroke was $2059.67 billion or 1.66% of the global GDP. Global VLW/GDP for stroke subtypes was 0.78% (VLW=$964.51 billion) for ischemic stroke, 0.71% (VLW=$882.81 billion) for intracerebral hemorrhage, and 0.17% (VLW=$212.36 billion) for subarachnoid hemorrhage. The Central European, Eastern European, and Central Asian GBD super-region reported the highest VLW/GDP for stroke overall (3.01%), ischemic stroke (1.86%), and for subarachnoid hemorrhage (0.26%). The Southeast Asian, East Asian, and Oceanian GBD super-region reported the highest VLW/GDP for intracerebral hemorrhage (1.48%).

conclusionsThe global macroeconomic consequences related to stroke are vast even when considering stroke subtypes. The present quantification may be leveraged to help justify increased spending of finite resources on stroke in an effort to improve outcomes for patients with stroke globally.

Indexed as

Ischemic StrokeStrokeSubarachnoid HemorrhageCerebral HemorrhageGlobal HealthHumansdisability-adjusted life yearsglobal healthhealth economicsstroke

Identifiers

PMID37497672
PMCPMC7614992

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