Evidence map›Paper›PMID 37497519›Full record

ArticleBiomedical optics express2023

Highly sensitive and label-free detection of biotin using a liquid crystal-based optofluidic biosensor.

Haonan Wang, Tianhua Xu, Ziyihui Wang, Yize Liu, Huaixu Chen, Junfeng Jiang, Tiegen Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical optics express, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Haonan WangSchool of Precision Instrument and Opto-Electronics Engineering, Tianjin University, Tianjin, 300072, China.
Tianhua XuSchool of Precision Instrument and Opto-Electronics Engineering, Tianjin University, Tianjin, 300072, China.ORCID https://orcid.org/0000-0002-5510-841X
Ziyihui WangSchool of Precision Instrument and Opto-Electronics Engineering, Tianjin University, Tianjin, 300072, China.
Yize LiuSchool of Precision Instrument and Opto-Electronics Engineering, Tianjin University, Tianjin, 300072, China.
Huaixu ChenSchool of Precision Instrument and Opto-Electronics Engineering, Tianjin University, Tianjin, 300072, China.
Junfeng JiangSchool of Precision Instrument and Opto-Electronics Engineering, Tianjin University, Tianjin, 300072, China.ORCID https://orcid.org/0000-0003-0393-8451
Tiegen LiuSchool of Precision Instrument and Opto-Electronics Engineering, Tianjin University, Tianjin, 300072, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A liquid crystal (LC)-based optofluidic whispering gallery mode (WGM) resonator has been applied as a biosensor to detect biotin. Immobilized streptavidin (SA) act as protein molecules and specifically bind to biotin through strong non-covalent interaction, which can interfere with the orientation of LCs by decreasing the vertical anchoring force of the alignment layer in which the WGM spectral wavelength shift is monitored as a sensing parameter. Due to the double magnification of the LC molecular orientation transition and the resonance of the WGM, the detection limit for SA can reach 1.25 fM (4.7 × 10

Identifiers

PMID37497519
PMCPMC10368036

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.