Evidence map›Paper›PMID 37497493›Full record

ArticleBiomedical optics express2023

Methods for real-time feature-guided image fusion of intrasurgical volumetric optical coherence tomography with digital microscopy.

Robert M Trout, Christian Viehland, Jianwei D Li, William Raynor, Al-Hafeez Dhalla, Lejla Vajzovic, Anthony N Kuo, Cynthia A Toth, Joseph A Izatt

Erratum issued Registry-linked trialAbstract read
In one paragraph

Article in Biomedical optics express, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT07024719 (First Use of Duke 4D Microscope Integrated OCT), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07024719 narecruitingnot on this mapstarted 2025, after this paper: background citation

First Use of Duke 4D Microscope Integrated OCT (MIOCT) Integrated Into Zeiss Artevo 800 Ophthalmic Surgical Microscope in the Operating Room

TypeinterventionalSponsorDuke UniversityRan2025 to 2026Enrolled5ConditionsCorneal Diseases, Retinal Diseases, Ocular DiseasesArms4D MIOCT integrated into a Zeiss Artevo 800
3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. New Directions for Ophthalmic OCT - Handhelds, Surgery, and Robotics.Translational vision science & technology · 2025
    Review
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Robert M TroutDepartment of Biomedical Engineering, Duke University, 101 Science Drive, Durham, NC 27708, USA.ORCID https://orcid.org/0000-0002-6798-6607
Christian ViehlandDepartment of Biomedical Engineering, Duke University, 101 Science Drive, Durham, NC 27708, USA.
Jianwei D LiDepartment of Biomedical Engineering, Duke University, 101 Science Drive, Durham, NC 27708, USA.
William RaynorDepartment of Ophthalmology, Duker University Medical Center, 2351 Erwin Road, Durham, NC 27705, USA.
Al-Hafeez DhallaDepartment of Biomedical Engineering, Duke University, 101 Science Drive, Durham, NC 27708, USA.
Lejla VajzovicDepartment of Ophthalmology, Duker University Medical Center, 2351 Erwin Road, Durham, NC 27705, USA.
Anthony N KuoDepartment of Biomedical Engineering, Duke University, 101 Science Drive, Durham, NC 27708, USA.
Cynthia A TothDepartment of Biomedical Engineering, Duke University, 101 Science Drive, Durham, NC 27708, USA.
Joseph A IzattDepartment of Biomedical Engineering, Duke University, 101 Science Drive, Durham, NC 27708, USA.

Funding

Intraoperative OCT Guidance of Intraocular SurgeryU01EY028079 · NEI · DUKE UNIVERSITY · PI KUO, ANTHONY NANLIN, TOTH, CYNTHIA ANN · 2018 to 2022
$3.8M
NEI NIH HHS U01 EY028079
6 · The paper itself

Abstract

4D-microscope-integrated optical coherence tomography (4D-MIOCT) is an emergent multimodal imaging technology in which live volumetric OCT (4D-OCT) is implemented in tandem with standard stereo color microscopy. 4D-OCT provides ophthalmic surgeons with many useful visual cues not available in standard microscopy; however it is challenging for the surgeon to effectively integrate cues from simultaneous-but-separate imaging in real-time. In this work, we demonstrate progress towards solving this challenge via the fusion of data from each modality guided by segmented 3D features. In this way, a more readily interpretable visualization that combines and registers important cues from both modalities is presented to the surgeon.

Identifiers

PMID37497493
PMCPMC10368056

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.