ReviewFrontiers in neurology2023
Top-down and bottom-up stimulation techniques combined with action observation treatment in stroke rehabilitation: a perspective.
Review in Frontiers in neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Effects of repetitive transcranial magnetic stimulation combined with repetitive peripheral magnetic stimulation on upper limb motor function after stroke: a systematic review and meta-analysis.Frontiers in neurology · 2024Pooled it
- Effect of robot-assisted gait training combined with electroacupuncture on lower limb motor function and brain network characteristics in stroke: an EEG study.Journal of neuroengineering and rehabilitation · 2025Trial
- Bilateral intermittent theta-burst stimulation as a priming strategy to enhance action observation and imitation training in early parkinson's disease: a proof-of-concept study.Journal of neuroengineering and rehabilitation · 2025Trial
- EEG Biomarkers During Upper-Limb Action Observation Therapy for Stroke Rehabilitation: A Scoping Review.Annals of biomedical engineering · 2026Review
- Differential cortical responses to neuromuscular electrical vs. peripheral magnetic stimulation: a multimodal TMS-fNIRS study.Frontiers in neuroscience · 2026Article
- Motor network pre-habilitation by low-frequency repetitive transcranial magnetic stimulation. A proof-of-concept.Acta neurochirurgica · 2025Article
- The Effect of Peripheral Magnetic Stimulation on Functional Mobility and Morphology in Cerebral Palsy with Spastic Diplegia: A Randomized Controlled Trial.Life (Basel, Switzerland) · 2025Article
- Neurorehabilitation of Visual Neglect: A Narrative Review of Approaches from A.R. Luria to Modern Clinical Protocols.Consortium psychiatricum · 2025Review
- Impact of transcranial direct current stimulation combined with median nerve stimulation on CRS-R in patients with prolonged disorders of consciousness after cerebral hemorrhage: protocol for a randomized controlled trial.Frontiers in neurology · 2025Article
- rTMS combined with median nerve magnetic stimulation for prolonged disorders of consciousness following intracerebral hemorrhage: a randomized controlled trial protocol.Frontiers in neurology · 2025Article
- The Impact of Persevering Home Full-Body In-Bed Gym Exercise on Body Muscles in Aging: A Case Report by Quantitative Radio-Densitometric Study Using 3D and 2D Color CT.Diagnostics (Basel, Switzerland) · 2024Article
- Distinct Effects of Brain Activation Using tDCS and Observational Practice: Implications for Motor Rehabilitation.Brain sciences · 2024Article
- Effects of low-frequency rTMS combined with speech and language therapy on Broca's aphasia in subacute stroke patients.Frontiers in neurology · 2024Article
- Balance of power: The choice between trial and participant numbers to optimise the detection of phase-dependent effects.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Effects of acupoints-based TENS combined with tDCS on spasticity and motor function in ischemic stroke with spastic hemiplegia: study protocol for a randomized controlled trial.Frontiers in neurology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stroke is a central nervous system disease that causes structural lesions and functional impairments of the brain, resulting in varying types, and degrees of dysfunction. The bimodal balance-recovery model (interhemispheric competition model and vicariation model) has been proposed as the mechanism of functional recovery after a stroke. We analyzed how combinations of motor observation treatment approaches, transcranial electrical (TES) or magnetic (TMS) stimulation and peripheral electrical (PES) or magnetic (PMS) stimulation techniques can be taken as accessorial physical therapy methods on symptom reduction of stroke patients. We suggest that top-down and bottom-up stimulation techniques combined with action observation treatment synergistically might develop into valuable physical therapy strategies in neurorehabilitation after stroke. We explored how TES or TMS intervention over the contralesional hemisphere or the lesioned hemisphere combined with PES or PMS of the paretic limbs during motor observation followed by action execution have super-additive effects to potentiate the effect of conventional treatment in stroke patients. The proposed paradigm could be an innovative and adjunctive approach to potentiate the effect of conventional rehabilitation treatment, especially for those patients with severe motor deficits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.