Evidence map›Paper›PMID 37497012›Full record

ArticleFrontiers in neurology2023

Ketogenic dietary therapies in epilepsy: recommendations of the Italian League against Epilepsy Dietary Therapy Study Group.

Valentina De Giorgis, Anna Tagliabue, Francesca Bisulli, Ilaria Brambilla, Alessandra Camerini, Raffaella Cusmai, Francesca Darra, Alice Dianin, Elia Domenica, Monica Anna Maria Lodi and 10 more

Abstract read
In one paragraph

Article in Frontiers in neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Holistic management of epilepsy in adults with intellectual development disorders.Epileptic disorders : international epilepsy journal with videotape · 2026
    Article
  4. Review
  5. Review
  6. Classic or classical ketogenic diet? Definitions and nomenclature.Epileptic disorders : international epilepsy journal with videotape · 2025
    Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Valentina De GiorgisDepartment of Brain and Behaviour Neuroscience, University of Pavia, Pavia, Italy.
Anna TagliabueDepartment of Public Health, Human Nutrition and Eating Disorder Research Center and Ketogenic Metabolic Therapy Laboratory-Experimental and Forensic Medicine University of Pavia, Pavia, Italy.
Francesca BisulliIRCCS Istituto delle Scienze Neurologiche di Bologna, Full Member of the European Reference Network for Rare and Complex Epilepsies (EpiCARE), Bologna, Italy.
Ilaria BrambillaEndocrinologia, Diabetologia e Ginecologia Pediatrica, Fondazione IRCCS Policlinico San Matteo di Pavia, Università degli Studi di Pavia, Pavia, Italy.
Alessandra CameriniItalian GLUT1-DS Association, Milan, Italy.
Raffaella CusmaiChild Neurology Unit, Department of Neuroscience and Neurorehabilitation, Bambino Gesù Children's Research Hospital, IRCCS, Rome, Italy.
Francesca DarraChild Neuropsychiatry Unit, Department of Engineering for Innovation Medicine, University of Verona, Full Member of European Reference Network EpiCARE, Verona, Italy.
Alice DianinInherited Metabolic Diseases Unit and Regional Centre for Newborn Screening, Diagnosis and Treatment of Inherited Metabolic Diseases and Congenital Endocrine Diseases, Azienda Ospedaliera Universitaria Integrata, Verona, Italy.
Elia DomenicaArtificial Nutrition Unit, Bambino Gesù Children's Hospital IRCCS, Rome, Italy.
Monica Anna Maria LodiDepartment of Child Neuropsychiatry, Epilepsy Center, Fatebenefratelli Hospital, Milan, Italy.
Sara MatricardiDepartment of Pediatrics, University of Chieti, Chieti, Italy.
Tullio MessanaIstituto delle Scienze Neurologiche di Bologna, UOC Neuropsichiatria dell'etá pediatrica, Member of the ERN Epicare, Bologna, Italy.
Francesca OpertoDepartment of Science of Health, School of Medicine, University Magna Graecia of Catanzaro, Catanzaro, Italy.
Francesca RagonaDepartment of Pediatric Neurology, IRCCS Foundation Carlo Besta Neurological Institute, Milan, Italy.
Emilio RussoScience of Health Department, University of Catanzaro, Catanzaro, Italy.
Costanza VaresioDepartment of Brain and Behaviour Neuroscience, University of Pavia, Pavia, Italy.
Lilia VolpiUOC Neurologia, IRCCS Istituto delle Scienze Neurologiche, Azienda USL di Bologna, Ospedale Bellaria Bologna, Bologna, Italy.
Martina Paola ZanaboniChild Neurology and Psychiatry Unit, IRCCS Mondino Foundation, Pavia, Italy.
Ludovica PascaDepartment of Brain and Behaviour Neuroscience, University of Pavia, Pavia, Italy.
Pierangelo VeggiottiVittore Buzzi Children's Hospital, Pediatric Neurology Unit, Milan, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A stepwise increase in the utilization of ketogenic dietary therapies for drug-resistant epilepsy has been observed in Italy in the last decade, although it is still considered often underused in many centers when compared to other countries. The Dietary Therapy Study Group of the Italian League against Epilepsy proposes practical recommendations to improve shared knowledge and facilitate the application of ketogenic dietary therapies, optimizing its efficacy and tolerability. The experts involved (11 child neuropsychiatrists, two adult neurologists, one psychologist, one pharmacologist, one pediatric endocrinologist, one representative of patients' associations, and three dietitians and clinical nutritionists) responded to a survey on current clinical practice issues and were asked to discuss controversial topics related to supplementation, long-term maintenance, transition, and a multidisciplinary approach to ketogenic dietary therapies. Practical indications for patient selection, diet initiation, management, side effects prevention, and follow-up are provided.

Indexed as

consensusdrug resistant epilepsyKetogenic dietary therapiesmultidisciplinary approachrecommendationstarget treatment

Identifiers

PMID37497012
PMCPMC10368245

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.