Evidence map›Paper›PMID 37496954›Full record

ArticleOrganic process research & development2023

Practical and Scalable Two-Step Process for 6-(2-Fluoro-4-nitrophenyl)-2-oxa-6-azaspiro[3.3]heptane: A Key Intermediate of the Potent Antibiotic Drug Candidate TBI-223.

Flavio S P Cardoso, Appasaheb L Kadam, Ryan C Nelson, John W Tomlin, Dipendra Dahal, Christopher S Kuehner, Gard Gudvangen, Anthony J Arduengo, Justina M Burns, Sarah L Aleshire and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Organic process research & development, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Flavio S P CardosoMedicines for All Institute, Virginia Commonwealth University, 737 N. 5th St., Box 980100, Richmond, Virginia 23298, United States.ORCID https://orcid.org/0000-0002-8608-5054
Appasaheb L KadamMedicines for All Institute, Virginia Commonwealth University, 737 N. 5th St., Box 980100, Richmond, Virginia 23298, United States.ORCID https://orcid.org/0000-0002-0452-2901
Ryan C NelsonMedicines for All Institute, Virginia Commonwealth University, 737 N. 5th St., Box 980100, Richmond, Virginia 23298, United States.
John W TomlinMedicines for All Institute, Virginia Commonwealth University, 737 N. 5th St., Box 980100, Richmond, Virginia 23298, United States.ORCID https://orcid.org/0000-0001-5135-3015
Dipendra DahalSchool of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332-0400, United States.
Christopher S KuehnerSchool of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332-0400, United States.ORCID https://orcid.org/0000-0001-5022-7682
Gard GudvangenSchool of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332-0400, United States.
Anthony J ArduengoSchool of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332-0400, United States.ORCID https://orcid.org/0000-0003-4922-2694
Justina M BurnsMedicines for All Institute, Virginia Commonwealth University, 737 N. 5th St., Box 980100, Richmond, Virginia 23298, United States.
Sarah L AleshireMedicines for All Institute, Virginia Commonwealth University, 737 N. 5th St., Box 980100, Richmond, Virginia 23298, United States.ORCID https://orcid.org/0000-0001-5353-4063
David R SneadMedicines for All Institute, Virginia Commonwealth University, 737 N. 5th St., Box 980100, Richmond, Virginia 23298, United States.ORCID https://orcid.org/0000-0003-1239-533X
Fengrui QuDepartment of Chemistry and Biochemistry, The University of Alabama, Tuscaloosa, Alabama 35487-0336, United States.
Ken BelmoreDepartment of Chemistry and Biochemistry, The University of Alabama, Tuscaloosa, Alabama 35487-0336, United States.
Saeed AhmadMedicines for All Institute, Virginia Commonwealth University, 737 N. 5th St., Box 980100, Richmond, Virginia 23298, United States.
Toolika AgrawalDepartment of Chemistry, Virginia Commonwealth University, 1001 West Main Street, Richmond, Virginia 23284-3208, United States.
Joshua D SieberDepartment of Chemistry, Virginia Commonwealth University, 1001 West Main Street, Richmond, Virginia 23284-3208, United States.ORCID https://orcid.org/0000-0001-6607-5097
Kai Oliver DonsbachMedicines for All Institute, Virginia Commonwealth University, 737 N. 5th St., Box 980100, Richmond, Virginia 23298, United States.ORCID https://orcid.org/0000-0001-5942-1553

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A low-cost, protecting group-free route to 6-(2-fluoro-4-nitrophenyl)-2-oxa-6-azaspiro[3.3]heptane (

Identifiers

PMID37496954
PMCPMC10367134

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.