Evidence map›Paper›PMID 37496815›Full record

ArticleJGH open : an open access journal of gastroenterology and hepatology2023

A retrospective analysis of clinical outcomes between hospitalized patients with COVID-19 who received famotidine or pantoprazole.

Justin J Wagner, Nikolas St Cyr, Aaron Douen, Joshua Fogel, John Trillo

Open access · goldAbstract read
In one paragraph

Article in JGH open : an open access journal of gastroenterology and hepatology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Justin J WagnerDepartment of Medicine South Brooklyn Health Brooklyn New York USA.ORCID https://orcid.org/0000-0002-9519-4834
Nikolas St CyrDepartment of Medicine South Brooklyn Health Brooklyn New York USA.
Aaron DouenDepartment of Medicine South Brooklyn Health Brooklyn New York USA.
Joshua FogelDepartment of Business Management Brooklyn New York USA.
John TrilloDepartment of Medicine South Brooklyn Health Brooklyn New York USA.
Center for Brooklyn History · USBrooklyn Law School · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Aim: There is limited research on the use of histamine-H2 receptor antagonists and proton pump inhibitors for treating COVID-19. We compare clinical outcomes between patients hospitalized with COVID-19 receiving famotidine or pantoprazole. Methods: This retrospective study included 2184 patients (famotidine: Results: As compared to nonuse, famotidine (OR: 0.30, 95% CI: 0.20-0.44, Conclusions: Famotidine is associated with lower odds for all-cause mortality, mechanical ventilation, vasopressor use, acute kidney injury, and gastrointestinal bleeding as compared to pantoprazole in patients hospitalized with COVID-19. We recommend that clinicians consider the use of famotidine over pantoprazole for hospitalized COVID-19 patients. Future research with a clinical trial would be beneficial to further support such use of famotidine.

Indexed as

acute kidney injuryartificial respirationCOVID‐19famotidinegastrointestinal hemorrhagemortalitypantoprazole

Identifiers

PMID37496815
PMCPMC10366487
OpenAlexW4383877814

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.